CYTOKINE DYSREGULATION, VIRUSES, AND CHILDHOOD ASTHMA

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 (from ClinicalTrials.gov网站） 本研究不再招募受试者。 尽管哮喘可能是一种异质性疾病或综合征，但有三个因素和/或事件反复出现，它们能够显著影响生命最初十年的哮喘发病：免疫应答异常，似乎最好用细胞因子失调的概念来定义;下呼吸道感染，（特别是RSV）;以及需要在免疫系统或肺发育的关键时间段发生的某种形式的基因与环境相互作用。然而，这些因素中的任何一个或所有因素如何独立或相互作用地影响儿童哮喘的发生，仍有待确定。因此，我们努力确定和定义这三个因素对哮喘发病机制的重要性是目前拨款申请的重点和目标。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. (from ClinicalTrials.gov website) This study is no longer recruiting subjects. Although asthma is likely to be a heterogeneous disease or syndrome, three factors and/or events repetitively emerge for their ability to significantly influence asthma inception in the first decade of life: immune response aberrations, which appear to be defined best by the concept of cytokine dysregulation; lower respiratory tract infections (in particular RSV); and some form of gene by environment interaction that needs to occur at a critical time period in the development of the immune system or the lung. It remains to be firmly established, however, how any one or all of these factors, either independently or interactively, influence the development of childhood asthma. Thus, our efforts to determine and define the importance of these three factors to asthma pathogenesis are the focus and goal of this current grant application.