TESTING INFLAMMATORY POTENTIAL OF HYALURONAN-DERIVED VASCULAR IMPLANTS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 该项目的目的是在实验室中确定透明质酸衍生材料是否以及如何与人体血液中的白色血细胞相互作用，特别是如果材料诱导这些细胞的炎症特征。 Hybryonan是一种存在于皮肤组织中的化学物质。 Hybryonan可以在实验室中分离和改变，以提供一种材料，该材料可用于医疗器械，如用于治疗心血管疾病的血管移植物。 本研究的目的是进行实验室研究，以确定白色血细胞（白细胞）如何与透明质酸和其他与透明质酸基材料接触的血管细胞类型反应。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this project is to determine in the laboratory, if and how hyaluronan-derived materials interact with white blood cells in human blood, particularly if the material induces inflammatory characteristics among these cells. Hyaluronan is a chemical present in skin tissue. Hyaluronan can be isolated and altered in the laboratory to provide a material, which may be useful for medical devices such as vascular grafts used in treating cardiovascular disease. The goal of this research is to perform laboratory studies to determine how white blood cells (leukocytes) react with hyalruonan and other vascular cell types that are in contact with hyaluronan-based materials.