PHYSIOLOGIC RESPONSE TO INTERMITTENT CYCLIC HYPOXIA

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本研究将研究如何间歇性缺氧改变血流动力学，交感神经，认知和代谢功能的正常志愿者暴露于循环缺氧过夜28晚。暴露于间歇性缺氧是许多疾病状态的一部分，包括阻塞性睡眠呼吸暂停，并可能与某些环境暴露有关。对于间歇性低氧暴露如何改变血流动力学、交感神经、认知和代谢功能的了解有限。研究人员假设，间歇性循环缺氧，模仿阻塞性睡眠呼吸暂停发生的周期性去饱和，与血管张力，警觉性和记忆功能，交感神经激活和葡萄糖代谢的改变有关。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study will examine how intermittent hypoxia alters hemodynamic, sympathetic, cognitive and metabolic function in normal volunteers exposed to cyclic hypoxia overnight for 28 nights. Exposure to intermittent hypoxia occurs as part of many disease states, including obstructive sleep apnea and may be associated with some environmental exposures. There is limited understanding of how exposure to intermittent hypoxia alters hemodynamic, sympathetic, cognitive, and metabolic function. The researchers hypothesize that intermittent cyclic hypoxia, which mimics the periodic desaturations that occur with obstructive sleep apnea, is associated with alterations in vascular tone, alertness and memory function, sympathetic activation, and glucose metabolism.