ADOLESCENT DEVELOPMENT STUDY

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 该项目采用遗传高风险研究策略，以更好地了解精神病的脆弱性。 其主要目的是：1确定青少年和年轻成年后代和原发性精神病患者的兄弟姐妹的心理病理学和社会功能障碍的预测因子; 2表征精神病性障碍的神经发育底物，并确定神经变性是否与精神病相关; 3建立一个基础设施，以监测青少年精神病的遗传风险，以便未来的建议可以集中在早期干预方案上。 本研究旨在纳入129名13-25岁的青少年和成年人，他们是精神病患者的后代或兄弟姐妹，因此有精神病的遗传风险，以及161名低风险健康对照青少年和同龄的年轻人。 所有青少年和年轻成人受试者将接受基线评估，包括神经心理学、精神病倾向、心理社会和家庭功能测量。 所有青少年和年轻成人受试者还将在MGH接受结构和功能磁共振成像MRI评价。 他们的父母或照顾者将被评估表达的情绪和沟通异常的措施。 将每隔6个月监测所有290名青少年和年轻成人受试者及其健康的父母或护理者的心理社会功能的临床显著变化。 所有青少年和年轻成人受试者将被要求在两年的随访中重复进行神经心理学和结构/功能MRI。考虑到精神障碍发病的年龄范围很广，将对获得的样本进行多年随访。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project employes a genetic high-risk research strategy to better understand vulnerability to psychosis. Its key aims are to: (1) identify predictors of physchopathology and social dysfunction in adolescent and young adult offspring and siblings of patients with primary psychotic disorders; (2) charactherize the neurodevelopmental substrates of psychotic disorders and determine if neurodegeneration is associated with psychosis onsent; (3) establish an infrastructure to monitor adolescents at genetic risk for pyschosis so that future proposals can focus on early intervention protocols. This study aims to included 129 adolescents and younge adults (13-25 years of age) who are either offspring or siblings of patients with psychotic disorders and thus at genetic risk for psychosis and 161 "low risk" healthy control adolescents and young adults of the same ages. All adolescent and young adult subjects will receive a baseline assessment that includes neuropsychological, psychosis proneness, psychosocial and family functioning measures. All adolescent and young adult subjects will also be evaluated with structural and functional magnetic resonance imaging (MRI) at MGH. Their parents or caregivers will be assessed with measures of expressed emotion and communication deviance. All 290 adolescent and young adult subjects and their well paretn or caregiver will be monitored for clinically significant changes psychosocial functioning at six-month intervals. All adolescent and young adult subjects will be asked to repeat a neuropsychological and structural/functional MRI for a two-year follow-up. Given the wide age range for the onset of psychotic disorders, the obtained sample will be followed for many years.