SENSORY AND EMOTION PROCESSING IN THE RISK FOR SCHIZOPHRENIA

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 该项目的目的是完善精神分裂症风险的神经认知标志物。认知功能的两个领域正在被研究作为精神分裂症遗传风险和临床风险的标志：1潜在抑制无关信息的能力; 2情绪信息背景下的工作记忆。此外，正在研究认知障碍的水平与临床风险水平的关系，如通过评估体型评估所测量的。 参与者是新招募的人员或正在进行的BIDMC批准的研究的后续人员：青少年发展研究。当后续受试者完成定期参与ADS时，将招募他们。更多的参与者将从大波士顿地区招募。总共将入组30名16-25岁的高风险青少年/青壮年和30名社区对照受试者。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The aim of this project is to refine neurocognitive markers of risk for schizophrenia. Two areas of cognitive functioning are being examined as markers of genetic risk and clinical risk for schizophrenia: 1) the ability to latently inhibit irrelevant information; 2) working memory in the context of emotional information. Further, level of cognitive impairment is being studied in association with level of clinical risk, as measure by assessments of schizotypy. Participants are new recruits or follow ups to an ongoing BIDMC approved study: The Adolescent Development Study. The follow-up subjects are recruited when they have completed their periodic participation in the ADS. Additional participants will be recruited from the greater Boston area. In total, 30 adolescents/young adults (age 16-25) at high risk and 30 community control participants will be enrolled.