GROWTH HORMONE AND INSULIN RESISTANCE IN GIRLS WITH TURNER SYNDROME

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 胰岛素抵抗(IR)与肌肉中特殊的脂肪储存有关，这可以通过MRI来测量。生长激素(GH)治疗也会导致IR。在这项研究中，我们将确定生长激素如何影响接受生长激素治疗的女孩的肌肉脂肪储存，无论是在生长激素治疗期间还是在没有生长激素治疗期间。评估包括对肌肉脂肪的核磁共振分析、胰岛素敏感性和身体成分。我们的研究旨在帮助我们了解生长激素是如何引起胰岛素抵抗的，并可能导致增加其安全性和有效性的方法。本研究的目的是确定GH如何影响MRI测量的心肌细胞内脂质(IMCL)，评估IMCL含量作为Turner综合征IR的决定因素，并评估GH治疗在这种关系中的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Insulin Resistance (IR) is associated with special stores of fat in muscle, which can be measured by MRI. Growth hormone (GH) treatment can also cause IR. In this study, we will determine how GH affects muscle fat stores in girls receiving GH for short stature, both during and without GH treatment. Assessments include analyses of muscle fat by MRI, insulin sensitivity, and body composition. Our studies are intended to help us understand how GH causes IR and may lead to ways to increase its safety and effectiveness. Goal of the study is to determine how GH affects intramyocellular lipid (IMCL) as measured by MRI and to evaluate IMCL content as a determinant of IR in Turner Syndrome and to assess the impact of GH therapy in this relationship.