GH AND INSULIN RESISTANCE IN GIRLS WITH TURNER SYNDROME OR ISS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 胰岛素抵抗（IR）与肌肉中特殊的脂肪储存有关，这可以通过MRI测量。生长激素（GH）治疗也可能导致IR。在这项研究中，我们将确定生长激素如何影响肌肉脂肪储存在女孩接受生长激素身材矮小，无论是在和没有生长激素治疗。评估包括通过MRI分析肌肉脂肪、胰岛素敏感性和身体成分。我们的研究旨在帮助我们了解GH如何导致IR，并可能导致增加其安全性和有效性的方法。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Insulin resistance (IR) is associated with special stores of fat in muscle, which can be measured by MRI. Growth hormone (GH) treatment can also cause IR. In this study, we will determine how GH affects muscle fat stores in girls receiving GH for short stature, both during and without GH treatment. Assessments include analyses of muscle fat by MRI, insulin sensitivity, and body composition. Our studies are intended to help us understand how GH causes IR and may lead to ways to increase its safety and effectiveness.