EFFECTS OF DHA

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 主要目的：通过ADAS-Cog和CDR-EEG评分的变化，确定DHA 1 g bid治疗是否能改善AD患者的认知功能。 次要目标： 1.使用这些机制的经验证的生物标志物（MRI衍生的脑萎缩率、CSF β淀粉样蛋白、tau、p-tau、F2异前列烷和神经前列烷）来确定长期DHA补充剂是否发挥抗淀粉样蛋白、抗氧化剂或神经保护作用。 2.研究长期补充DHA对血浆和尿液中氧化损伤标志物（血浆F_4神经前列腺素和尿F_2异前列腺素）的影响。 3.确定长期补充DHA对其他相关微量元素（维生素C、维生素E、类胡萝卜素）的影响及其在AD进展中的作用。 4.研究长期补充DHA对AD患者的功能损害（ADCS-ADL）、精神共病（NPI）和生活质量（QOL）的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Primary Aim: To determine whether treatment with DHA 1 gram bid improves cognitive function in patients with AD, as indicated by changes in scores on the ADAS-Cog and CDR-SOB. Secondary Aims: 1.To determine if chronic DHA supplementation exerts anti-amyloid, antioxidant or neuroprotective effects using validated biomarkers of these mechanisms (MRI-derived rates of brain atrophy, CSF beta amyloid, tau, p-tau, F2 isoprostanes, and neuroprostanes). 2.To determine the effects of chronic DHA supplementation on plasma and urine biomarkers of oxidative damage (plasma F4 neuroprostanes and urine F2 isoprostanes). 3.To determine the effects of chronic DHA supplementation on other relevant micronutients and their role in AD progression (Vitamin C, Vitamin E, carotenoids). 4.To determine the effect of chronic DHA supplementation on measures of functional impairment (ADCS-ADL), psychiatric comorbidities in AD (NPI), and quality of life (QOL).