COBRE: UID: MOLECULAR & CELLULAR BASIS OF HOST PATHOGEN INTERACTIONS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 通过促进我们的人员和基础设施基地的建设，Cobre在过去五年中的支持对爱达荷大学的微生物发病机制研究产生了重大影响。除了在最初的资助期间增加了两名由Cobre资助的新调查人员外，我们的大学管理部门还与Cobre PI合作，在过去四年中增设了四个终身教职跟踪职位。有了这个新的有才华的教员团队和我们Cobre教员的成功，我们已经在建立UI作为一个拥有国家认可的专注于微生物发病机制的生物医学计划的机构方面取得了进展。为了在此基础上取得成功，我们提出了四个具体目标。具体目标1：扩大科布雷联合调查员核心小组的临界人数和科学多样性。为了实现这一目标，我们建议增加我们现有的Cobre团队，为最近聘用的教职员工以及目前没有得到NIH资助的更成熟的教职员工提供研究支持，并增加一名待确定的人员。具体目标2：扩大和支持科布雷资助的核心设施。在Cobre和用户界面的支持下，我们能够利用私人资金建立几个最先进的核心设施，包括结构生物学、显微镜、细胞分离和基因组学核心设施。在这份提案中，我们描述了扩大和/或支持这些设施的计划，以确保Cobre和UI所做的初始投资有效地加强Cobre研究人员和其他生物医学研究人员在校园中的研究。具体目标3：提高研究生/医学生参与生物医学研究的质量和数量。自Cobre资助周期开始以来，随着我们能够招聘到的高素质研究生人数的增加，我们将使用额外的Cobre资金来进一步加强我们的毕业生招聘工作。这将通过增加津贴，促进在美国和国际上的招聘，以及与爱达荷州INBRES研究生教育管道项目的接口来实现。具体目标4：在科布雷基金完成后，向国家卫生研究院提供的自给自足的生物医学研究支持过渡。这一最终目标将有助于将Cobre调查人员确立为独立研究人员，最终目标是从NIH获得长期计划项目支持。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. By facilitating the building of our personnel and infrastructure bases, COBRE support over the past five years has had a significant impact on research in microbial pathogenesis at the University of Idaho. In addition to two new COBRE-funded investigators added during the initial funding period, our university administration has partnered with the COBRE PI to create four additional tenure-track positions during the past four years. With this new group of talented faculty and the success of our COBRE faculty we have made progress toward establishing the UI as an institution with a nationally recognized biomedical program with a focus on microbial pathogenesis. To build upon this success, we propose four specific aims. Specific Aim 1: Extend the critical mass and expand the scientific diversity of the core group of COBRE co-Investigators. In this aim we propose to add to our existing COBRE team by providing research support for the recently hired faculty members, as well as more established faculty members not currently funded by NIH, and an additional person to be identified. Specific Aim 2: Expand and support COBRE funded core facilities. With COBRE and UI support, we were able to leverage private funding to build several state-of-the-art core facilities, including Structural Biology, Microscopy, Cell Separation, and Genomics Core Facilities. In this proposal, we describe plans to expand and/or support these facilities to ensure that initial investments made by COBRE and the UI efficiently enhance research of COBRE investigators and other biomedical investigators on campus. Specific Aim 3: Enhance the quality and numbers of graduate/medical students to participate in biomedical research. With the documented increase in higher quality graduate students we have been able to recruit since the beginning of the COBRE funding cycle, we will use additional COBRE funds to further enhance our graduate recruiting efforts. This will be done by enhancing stipends, promoting recruitment in the U.S. and internationally, plus interfacing with the Idaho INBREs Pipeline to Graduate Education program. Specific Aim 4: Transition toward self-sustaining biomedical research support from the National Institutes of Health following completion of COBRE funds. This final aim will help to establish the COBRE investigators as independent researchers with the ultimate goal of obtaining long-term program project support from the NIH.