COBRE: UD: ADMININSTRATION CORE: OSTEOARTHRITIS: PREVENTION AND TREATMENT

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 我们建议在特拉华州大学建立一个生物医学卓越研究中心，该中心将专注于骨关节炎的预防和治疗。该提案涉及四个研究项目，每个项目由一名初级教师领导，由高级教师指导。 在第一个项目中，Novotny博士将使用动物模型来检查软骨组织的机械特性。在第二个项目中，Manal博士建议使用基于MRI和肌电图数据的生物力学模型来检查膝关节运动学和动力学，同时进行日常生活活动。在我们的第三个项目中，Royer博士建议检查膝关节OA患者的鞋内楔形物对静态对线测量的影响。此外，还将研究这种治疗的长期效果。在第四个项目中，Rudolph博士将研究膝内翻（“弓形腿”），这通常会导致膝关节内侧间室的关节炎。本研究的目的是描述开放楔形截骨术结合骨痂牵引矫正内翻前后运动和肌肉活动的差异。 除了四个项目外，核心还包括两个共享设施：步态分析实验室和步态和运动生物力学实验室。行政核心还资助小型试点项目。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We propose to establish a center of biomedical research excellence at the University of Delaware that will focus on the prevention and treatment of osteoarthritis. This proposal involves four research projects, each lead by a junior faculty member who will be mentored by senior faculty. In project one, Dr. Novotny will use an animal model to examine the mechanical properties of cartilage tissue. In the second project, Dr. Manal proposes to use a biomechanical model based on MRI and electromyographic data to examine knee kinematics and kinetics while performing activities of daily living. In our third project, Dr. Royer proposes to examine the examine the effects of in-shoe wedges in patients with knee OA on static alignment measures. In addition, the long-term effect of this treatment will also be examined. In the fourth project, Dr. Rudolph will study genu varum ("bowleggedness"), which often leads to arthritis on the medial compartment of the knee. The purpose of this study is to characterize the differences in movement and muscle activity before and after an opening wedge osteotomy with callus distraction to correct genu varum. In addition to the four projects, the core consists of two shared facilities: a Gait Analysis Lab and a Posture and Movement Biomechanics Lab. The Administrative core also funds small pilot projects.