GERIATRIC EXERCISE TRAINING FOR FITNESS (GETFIT)

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 50岁以上的美国艾滋病患者人数增加了5倍多。感染艾滋病毒的老年人的预后比年轻人差。随着抗逆转录病毒疗法的进步和人口的老龄化，感染艾滋病毒的美国老年人的人数将进一步增加，这明确表明需要采取与年龄有关的干预措施。人们对年龄对艾滋病毒感染者功能表现的影响以及运动训练是否可以改善老年艾滋病毒感染者明显的身体失调知之甚少。从拟议的研究结果将开始，以确定关键因素的复杂关系，老龄化，艾滋病毒和共病及其对身体功能的影响。我们将对90名年龄在21岁至50岁以上的HIV感染者进行横断面研究，以确定衰老对HIV感染者身体功能（峰值有氧能力）和身体成分的影响。我们假设，老年艾滋病毒感染者的身体功能加速下降，这在一定程度上可以通过运动康复干预来改变。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The number of Americans over age 50 with AIDS has increased more than 5-fold. Older adults with HIV have a worse prognosis than their younger counterparts. With advances in antiretroviral therapy, and the graying of the population, the number of HIV-infected older Americans will increase even further, clearly defining a need for age-related interventions. Little is known about the impact of age on functional performance in HIV-infected individuals and whether exercise training can ameliorate the marked physical deconditioning in older HIV-infected patients. Results from the proposed research will begin to identify the critical factors in the complex relationship of aging, HIV, and comorbid disease and their effect on physical functioning. We will conduct a cross-sectional study of 90 HIV-infected adults aged 21 to 50+ years to determine the effect of aging on physical functioning (peak aerobic capacity) and body composition in HIV-infected adults. We hypothesize that older HIV-infected individuals have an accelerated decline in physical functioning that is in part modifiable with exercise rehabilitation interventions.