PREVALENCE OF CYSTIC FIBROSIS RELATED DIABETES AMONG NATIVE AMERICANS IN OK

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 囊性纤维化相关糖尿病(CFRD)正日益成为囊性纤维化(CF)的常见并发症。CFRD的病理生理学机制尚不清楚；然而，2型DM的遗传风险已被提出理论，但仍未得到证实。这项研究的目标是估计合并糖耐量受损(IGT)或囊性纤维化相关糖尿病的患者的比例。糖耐量状态和自我报告的种族，特别是美洲原住民后裔之间的关系将被用来确定遗传性糖尿病易感性的可能性。糖耐量状态将通过2小时的口服葡萄糖耐量试验(OGTT)来确定，并与美洲原住民的种族状况相关。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cystic fibrosis related diabetes (CFRD) is becoming an increasingly common complication of cystic fibrosis (CF). The pathophysiology of CFRD remains unclear; however an inherited risk for type 2 DM has been a proposed theory, yet it remains unproven. The goal of this study is to estimate the proportion of patients with CF and impaired glucose tolerance (IGT) or cystic fibrosis related diabetes. The relationship between glucose tolerance status and self reported ethnicity, particularly of Native American descent will be used to determine the possibility of an inherited predisposition to diabetes. Glucose tolerance status will be determined by using a 2 hour oral glucose tolerance test (OGTT) and correlated with Native American ethnicity status.