FAMILIAL SCHIZOPHRENIA AND SPECTRUM PERSONALITY DISORDERS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 目前的项目计划在一大批受精神分裂症影响的家庭中检查大量的内表型。这将使我们能够搜索与每一种独立的内表型相关的基因，以及它们之间的相互作用。我们建议招募150个病例家系(即，有精神分裂症先证者的家庭)、150个对照家庭和30个对照受试者，他们在没有精神分裂症家族史的情况下表现出精神分裂症谱系人格症状。参与者将接受一系列临床、电生理、知觉和认知评估。这些数据将被用来识别可能与精神分裂症遗传风险相关的表型，并确定这些表型如何在家庭中聚集。测试程序需要10-12小时的承诺时间，测试将在2天或更长时间内完成。参与者将被要求提供血液样本，并将其储存起来，用于未来的基因分析。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The current project plans to examine a large number of endophenotypes in a large cohort of families affected by schizophrenia. This will allow us to search for genes associated with each of the independent endophenotypes, and their interactions. We propose to recruit 150 case families (i.e., families with a schizophrenia proband), 150 control families, and 30 control subjects who exhibit schizophrenia specetrum personality symptoms in the absence of a family histrory of schizophrenia. Participants will undergo a number of clinical, electrophysiological, perceptual, and cognitive assessments. These data will be used to identify phenotypes likely to be associated with genetic risk for schizophrenia, and to determine how these phenotypes aggregate in families. Testing procedures require a 10-12 hour time committment and testing will be completed over 2 or more days. Participants will be asked to give a blood sample, which will be stored for future genetic analyses.