LH SURGE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这项研究涉及详细的LH采样研究的老年和中年育龄妇女谁已启动与雌激素在高剂量和低剂量的范例。 该议定书有几个关键的困难，阻碍了及时完成，不幸的是，这些困难仍然存在。我们的类固醇输注不得不停止，由于不可预测的注入激素水平。妇女健康倡议临床试验的停止及其随之而来的负面宣传导致我们的志愿者人数减少，因为它涉及外源性雌二醇和孕酮的管理。当我们发现我们需要为其中一个子目标进行剂量反应研究的天然肽GnRH不在美国生产时，这种对研究的寒蝉效应才刚刚开始解除。今年将是招聘的最后一年。 2004年秋季提交了一份摘要。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study involves detailed LH sampling studies of older and mid-reproductive aged women who have been primed with estrogen in both high and lower-dose paradigms. This protocol has had several key difficulties that hampered timely completion and unfortunately thise difficulties continue. Our steroid infusions had to be stopped due to unpredictability of infused hormone levels. The stopping of the Women's Health Initiative Clinical Trial and its attendant negative publicity caused our volunteer pool to shrink from this study, since it involves the administration of exogenous estradiol and progesterone. This chilling effect on teh study was just beginning to lift when we discovered that the native peptide GnRH that we need to perform dose-response studies for one of the sub-aims is not in production in the US. This year will be the last year of recruitment. An abstract was presented in the Fall of 2004.