The Clinical Research/Reproductive Scientist Training Program (CREST)

描述（由申请人提供）：针对对内科科学家数量下降的担忧，生殖医学中相对缺乏精心设计和执行良好的临床和流行病学研究，以及目前妇产科生殖内分泌学和不孕症亚专业的学员选择退出研究职业道路的看法，临床研究/生殖科学家培训方案（CREST）方案是由国家儿童健康和人类发展研究所副所长、生殖和成人内分泌学方案、美国生殖医学学会和杜克大学临床研究培训方案组成并促进培训方案的关键组成部分之间建立的伙伴关系。教学培训模块设计为在线，以适应临床医生。周末研讨会与美国生殖医学协会年度会议（一年一次）和NIH校园（距离ASRM会议6个月）一起安排。毕业生将获得临床研究证书。在CREST的第二年，一个涉及大型数据集分析和技能获取测试的小组论文项目成为一项可选的非正式活动，在完成在线证书课程后进行。CREST项目的影响和结果是有希望的，并表明它正在实现其目标。目前的提案旨在使该计划的第二年正式纳入一个团队科学论文项目，并促进CREST学者新获得的技能的应用，以查询现有的人口和临床试验数据库并进行二次数据分析（具体目标1），并扩大CREST培训第二年的可用数据集，以包括生殖内分泌学和不孕症以及男科的多个数据源（具体目标2）。这些资源将为生育和避孕实践的结果分析提供描述性数据集，并为未来的研究产生新的假设。当前提案的目标与美国国立卫生研究院对生殖和怀孕研究的设想过程特别相关，该过程既认识到将怀孕视为生理压力源的重要性，又认识到将生命的孕前阶段作为怀孕健康和疾病的预测因素。

DESCRIPTION (provided by applicant): In response to concerns about the decline in physician scientists, the relative lack of well- designed and well-executed clinical and epidemiological research in reproductive medicine, and a perception that current trainees in the Reproductive Endocrinology and Infertility subspecialty of Obstetrics and Gynecology were opting out of research career paths, the Clinical Research/Reproductive Scientist Training Program (CREST) Program was established as a partnership among key components that comprised and facilitated the training program: the Deputy Director of the National Institute for Child Health and Human Development, the Program in Reproductive and Adult Endocrinology, the American Society for Reproductive Medicine, and the Clinical Research Training Program at Duke University. Didactic training modules are designed to be online to accommodate clinicians. Weekend seminars are scheduled in conjunction with the annual American Society for Reproductive Medicine meeting (once a year) and on the NIH campus (6 months apart from the ASRM meeting). Graduates receive a certificate in Clinical Research. A group thesis project involving analysis of a large data set and a testing of skill acquisition became an optional, informal activity in the second year of CREST, undertaken after completion of the online certificate program. The CREST Program's impact and outcomes are promising and indicate that it is achieving its goal. The present proposal seeks to formalize the second year of the program to specifically incorporate a team science thesis project and promote the application of CREST Scholars' newly acquired skills to query existing population and clinical trial databases and perform secondary data analyses (Specific Aim 1) and to expand the available data sets for the second year of CREST training to include multiple data sources in Reproductive Endocrinology and Infertility, and Andrology (Specific Aim #2). These resources will provide a descriptive dataset for outcomes analysis in fertility and contraceptive practice, and generate new hypotheses for future research. The goals of the current proposal are particularly relevant to the NIH visioning process for reproduction and pregnancy research, which has both recognized the importance of viewing pregnancy as a physiologic stressor, and examining the preconceptual phase of life as a predictor of pregnancy health and disease.