The Clinical Research/Reproductive Scientist Training Program (CREST)

描述(由申请人提供)：为了回应对以下问题的担忧：内科科学家的减少，生殖医学中相对缺乏精心设计和执行良好的临床和流行病学研究，以及人们认为目前在妇产科生殖内分泌学和不孕不育专科的学员正在选择退出研究职业道路，临床研究/生殖科学家培训计划(CREST)是作为组成和促进培训计划的关键组成部分之间的合作伙伴关系而建立的：国家儿童健康与人类发展研究所副所长，生殖和成人内分泌学计划，美国生殖医学学会，以及杜克大学的临床研究培训计划。教学培训模块设计为在线，以适应临床医生。周末研讨会安排在一年一度的美国生殖医学学会会议(每年一次)的同时，在NIH校园(ASRM会议间隔6个月)举行。毕业生获得临床研究证书。在CREST的第二年，一个涉及分析大量数据集和测试技能获得的小组论文项目成为一项可选的非正式活动，在完成在线证书课程后进行。CREST计划的影响和结果是有希望的，表明它正在实现其目标。本提案旨在使该计划的第二年正规化，以具体纳入一个团队科学论文项目，并促进CREST学者新获得的技能的应用，以查询现有的人口和临床试验数据库并进行二次数据分析(具体目标1)，并扩大第二年CREST培训的可用数据集，以包括生殖内分泌学和不孕症以及男科学(具体目标2)的多种数据源。这些资源将为生育和避孕实践中的结果分析提供描述性数据集，并为未来的研究产生新的假设。目前提案的目标与NIH生殖和怀孕研究的设想过程特别相关，该过程既认识到将怀孕视为生理应激源的重要性，也检查了生命的概念前阶段作为怀孕健康和疾病预测因素的重要性。

DESCRIPTION (provided by applicant): In response to concerns about the decline in physician scientists, the relative lack of well- designed and well-executed clinical and epidemiological research in reproductive medicine, and a perception that current trainees in the Reproductive Endocrinology and Infertility subspecialty of Obstetrics and Gynecology were opting out of research career paths, the Clinical Research/Reproductive Scientist Training Program (CREST) Program was established as a partnership among key components that comprised and facilitated the training program: the Deputy Director of the National Institute for Child Health and Human Development, the Program in Reproductive and Adult Endocrinology, the American Society for Reproductive Medicine, and the Clinical Research Training Program at Duke University. Didactic training modules are designed to be online to accommodate clinicians. Weekend seminars are scheduled in conjunction with the annual American Society for Reproductive Medicine meeting (once a year) and on the NIH campus (6 months apart from the ASRM meeting). Graduates receive a certificate in Clinical Research. A group thesis project involving analysis of a large data set and a testing of skill acquisition became an optional, informal activity in the second year of CREST, undertaken after completion of the online certificate program. The CREST Program's impact and outcomes are promising and indicate that it is achieving its goal. The present proposal seeks to formalize the second year of the program to specifically incorporate a team science thesis project and promote the application of CREST Scholars' newly acquired skills to query existing population and clinical trial databases and perform secondary data analyses (Specific Aim 1) and to expand the available data sets for the second year of CREST training to include multiple data sources in Reproductive Endocrinology and Infertility, and Andrology (Specific Aim #2). These resources will provide a descriptive dataset for outcomes analysis in fertility and contraceptive practice, and generate new hypotheses for future research. The goals of the current proposal are particularly relevant to the NIH visioning process for reproduction and pregnancy research, which has both recognized the importance of viewing pregnancy as a physiologic stressor, and examining the preconceptual phase of life as a predictor of pregnancy health and disease.