The Clinical Research/Reproductive Scientist Training Program (CREST)

描述（申请人提供）：针对以下关切：医生科学家人数减少，生殖医学方面相对缺乏精心设计和执行良好的临床和流行病学研究，以及认为目前妇产科生殖内分泌学和不孕不育子专业的受训人员选择退出研究职业道路，临床研究/生殖科学家培训计划（CREST）是作为组成和促进培训计划的关键组成部分之间的伙伴关系而建立的：国家儿童健康和人类发展研究所副主任，生殖和成人内分泌学项目，美国生殖医学学会，以及杜克大学的临床研究培训项目。教学培训模块设计为在线，以适应临床医生。周末研讨会与美国生殖医学学会年会（每年一次）和NIH校园（与ASRM会议相隔6个月）一起安排。毕业生获得临床研究证书。一个小组论文项目，涉及一个大型数据集的分析和技能获取的测试成为一个可选的，非正式的活动在CREST的第二年，完成在线证书课程后进行。CREST方案的影响和成果是有希望的，表明它正在实现其目标。目前的提案旨在正式确定该计划的第二年，专门纳入团队科学论文项目，并促进CREST学者新获得的技能的应用，以查询现有的人口和临床试验数据库，并进行二次数据分析（具体目标1）并扩大CREST培训第二年的可用数据集，以纳入生殖内分泌学的多个数据源，不孕不育和男科（具体目标#2）。这些资源将为生育和避孕实践的结果分析提供描述性数据集，并为未来的研究产生新的假设。当前提案的目标与NIH生殖和妊娠研究的远景规划过程特别相关，该过程既认识到将妊娠视为生理应激源的重要性，又认识到将生命的前概念阶段作为妊娠健康和疾病的预测因素。

DESCRIPTION (provided by applicant): In response to concerns about the decline in physician scientists, the relative lack of well- designed and well-executed clinical and epidemiological research in reproductive medicine, and a perception that current trainees in the Reproductive Endocrinology and Infertility subspecialty of Obstetrics and Gynecology were opting out of research career paths, the Clinical Research/Reproductive Scientist Training Program (CREST) Program was established as a partnership among key components that comprised and facilitated the training program: the Deputy Director of the National Institute for Child Health and Human Development, the Program in Reproductive and Adult Endocrinology, the American Society for Reproductive Medicine, and the Clinical Research Training Program at Duke University. Didactic training modules are designed to be online to accommodate clinicians. Weekend seminars are scheduled in conjunction with the annual American Society for Reproductive Medicine meeting (once a year) and on the NIH campus (6 months apart from the ASRM meeting). Graduates receive a certificate in Clinical Research. A group thesis project involving analysis of a large data set and a testing of skill acquisition became an optional, informal activity in the second year of CREST, undertaken after completion of the online certificate program. The CREST Program's impact and outcomes are promising and indicate that it is achieving its goal. The present proposal seeks to formalize the second year of the program to specifically incorporate a team science thesis project and promote the application of CREST Scholars' newly acquired skills to query existing population and clinical trial databases and perform secondary data analyses (Specific Aim 1) and to expand the available data sets for the second year of CREST training to include multiple data sources in Reproductive Endocrinology and Infertility, and Andrology (Specific Aim #2). These resources will provide a descriptive dataset for outcomes analysis in fertility and contraceptive practice, and generate new hypotheses for future research. The goals of the current proposal are particularly relevant to the NIH visioning process for reproduction and pregnancy research, which has both recognized the importance of viewing pregnancy as a physiologic stressor, and examining the preconceptual phase of life as a predictor of pregnancy health and disease.