The Clinical Research/Reproductive Scientist Training Program (CREST)

临床研究/生殖科学家培训计划 (CREST)

• 批准号: 10553877
• 负责人: Nanette F. Santoro
• 金额: $ 15.73万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-04-15 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10553877
• 关键词: Acceleration; American; Assisted Reproductive Technology; Attention; Behavioral Research; Behavioral Sciences; Biomedical Research; Biometry; Caring; Clinical; Clinical Investigator; Clinical Research; Clinical Sciences; Colorado; Committee Members; Communities; Data; Data Analyses; Department chair; Discipline of obstetrics; Distance Learning; Education Projects; Endocrinologist; Evolution; Fostering; Funding; Future; Goals; Gynecology; Home; Individual; Infertility; Institution; Investments; Journals; Leadership; Medical; Medicine; Mentors; Mentorship; Methodology; Multi-Institutional Clinical Trial; National Institute of Child Health and Human Development; Pathway interactions; Peer Review; Physicians; Practice Guidelines; Process; Professional Organizations; Program Evaluation; Protocols documentation; Publications; Reproductive Endocrinology; Reproductive Medicine; Research; Research Methodology; Research Personnel; Role; Scholars Program; Science; Scientist; Shapes; Societies; Structure; Time; Training; Training Programs; Underrepresented Populations; Universities; career; career development; clinical practice; design; equity, diversity, and inclusion; evidence base; experience; follow-up; improved; medical schools; medical specialties; member; next generation; patient population; programs; recruit; reproductive; response; senior faculty; success

PROJECT SUMMARY/ABSTRACT The Clinical Research/REproductive Scientist Training Program (CREST) has trained 88 physician scientists in the conduct of clinical research, has enabled these physicians to participate in multicenter clinical trials and secondary data analyses, and has helped further their careers and create a cadre of leaders in Obstetrics and Gynecology. Didactic training in biostatistical methodology is combined with a hands-on mentored team science project (MTSP) to guide Scholars through the data analysis and publication process. Throughout the program, mentorship and networking are emphasized to provide early career interactions with academic societies within their specialties and pathways to leadership. CREST Scholars have produced a total of 1,874 unique peer-reviewed publications since the start of the program in 2005. Specific aims of the current proposal will build upon past successes to: 1. Train the Reproductive Medicine workforce to meet the national need for clinical research. It is more critical than ever to educate trainees in clinical research and apply these principles to clinical practice. We shall continue to train up to 6 Scholars per year. 2. Promote diversity in the biomedical research workforce by recruiting and training Scholars who are underrepresented in Medicine (URiM) and equipping them for success. We shall improve our data capture and followup of URiMs recruited to CREST and apply best practice to welcome new URiM candidates to the program. 3. Provide ‘holistic’ mentoring for Scholars extending to their home institutions. We shall identify an experienced, senior faculty member who will provide one-on-one support for each Scholar’s research experience as well as longer term mentoring beyond the program’s 2-year time frame. By building upon our programmatic strengths and extending the reach of our mentoring protocols, we plan to continue our exceptional success in preparing for the future of the field. CREST has trained 7 academic Division Chiefs in Ob/Gyn, one department Chair, and two Presidents of the Society for Reproductive Endocrinology and Infertility to date, along with multiple committee members of the American Society for Reproductive Medicine.

项目总结/摘要 临床研究/生殖科学家培训计划（CREST）已经培训了88名医生科学家， 开展临床研究，使这些医生能够参加多中心临床试验， 二次数据分析，并帮助进一步他们的职业生涯，并创造了领导干部在产科和 妇科生物统计方法学的教学培训与实践指导团队相结合 科学项目（中期战略计划），以指导学者通过数据分析和出版过程。在整个 计划，导师和网络强调提供早期的职业互动与学术 社会在他们的专业和途径的领导。CREST学者总共产生了 自2005年该计划开始以来，有1，874篇独特的同行评审出版物。的具体目标 目前的建议将在过去成功的基础上：1。培训生殖医学工作人员，以满足 国家对临床研究的需求。对临床研究的培训比以往任何时候都更加重要 并将这些原则应用于临床实践。我们将继续每年培养多达6名学者。2.促进 生物医学研究人员的多样性，招聘和培训学者谁是 在医学（URiM）和装备他们的成功。我们将改进我们的数据 收集和跟踪招聘到CREST的URiM，并采用最佳做法欢迎新的URiM候选人 程序。3.为学者提供“全面”的指导，延伸到他们的家乡机构。我们 应确定一位经验丰富的资深教师，为每位学者提供一对一的支持。 研究经验以及超过该计划的2年时间框架的长期指导。通过建立 基于我们的计划优势和扩大我们的指导协议的范围，我们计划继续我们的 在为该领域的未来做准备方面取得了非凡的成功。CREST已经培训了7个学术部门的负责人， Ob/Gyn，一个系主任，两个生殖内分泌学会主席， 不孕症迄今为止，沿着多个委员会成员的美国社会生殖医学。

项目成果

Biomarkers of Stress and Male Fertility.

• DOI: 10.1007/s43032-022-00853-x
• 发表时间: 2022-04
• 期刊: Reproductive sciences (Thousand Oaks, Calif.)

Male vitamin D status and male factor infertility.

• DOI: 10.1016/j.fertnstert.2021.06.035
• 发表时间: 2021-10
• 期刊: Fertility and sterility
• 影响因子: 6.7
• 作者: Banks N;Sun F;Krawetz SA;Coward RM;Masson P;Smith JF;Trussell JC;Santoro N;Zhang H;Steiner AZ
• 通讯作者: Steiner AZ

Association of uterine fibroids and pregnancy outcomes after ovarian stimulation-intrauterine insemination for unexplained infertility.

子宫肌瘤与卵巢刺激宫内授精治疗不明原因不孕症后妊娠结局的关系。

• DOI: 10.1016/j.fertnstert.2016.12.012
• 发表时间: 2017
• 期刊: Fertility and sterility
• 影响因子: 6.7
• 作者: Styer,AaronK;Jin,Susan;Liu,Dan;Wang,Baisong;Polotsky,AlexJ;Christianson,MindyS;Vitek,Wendy;Engmann,Lawrence;Hansen,Karl;Wild,Robert;Legro,RichardS;Coutifaris,Christos;Alvero,Ruben;Robinson,RandalD;Casson,Peter;Christman,
• 通讯作者: Christman,

Lower antimüllerian hormone is associated with lower oocyte yield but not live-birth rate among women with obesity.

• DOI: 10.1016/j.ajog.2019.09.046
• 发表时间: 2020-04
• 期刊: American journal of obstetrics and gynecology
• 影响因子: 9.8
• 作者: Vitek W;Sun F;Baker VL;Styer AK;Christianson MS;Stern JE;Zhang H;Polotsky AJ
• 通讯作者: Polotsky AJ

Embryo cryopreservation and utilization in the United States from 2004-2013.

• DOI: 10.1016/j.xfre.2020.05.010
• 发表时间: 2020-09
• 期刊: F&S reports
• 作者: Christianson MS;Stern JE;Sun F;Zhang H;Styer AK;Vitek W;Polotsky AJ
• 通讯作者: Polotsky AJ