COBRE for Skeletal Health and Repair

描述(由申请人提供)：生物医学研究卓越中心(COBRE)的目标是建立一个多学科的转换研究中心，专注于软骨和关节健康与疾病机制，并开发修复策略。这些项目涵盖临床、生物和工程研究领域。项目1和项目2分析了骨骼发育过程中骨骼形成的长度。项目3和4检查成人关节疾病中关节软骨的退化情况。项目5研究如何修复和重建健康的软骨关节。研究人员和导师来自罗德岛医院/布朗医学院的五个科室(骨科、儿科、急诊医学、医学和生物工程)。初级调查人员包括三名临床医生/科学家和两名基础研究科学家。导师还包括临床医生/科学家和基础研究科学家。每位导师都是多项联邦拨款(NIH RO1或VA)的首席调查员。他们将监督初级研究员的研究项目，作为他们的榜样，并指导他们获得联邦研究项目拨款。我们的愿景是，通过建立这个研究基础设施，我们将使临床医生能够与基础研究科学家并肩工作，初级调查人员与高级调查人员并肩工作，生物学家与生物工程师并肩工作。这种多学科的方法对于制定预防和治疗骨骼关节疾病的翻译策略是绝对必要的。

DESCRIPTION (provided by applicant): The goal of the Center of Biomedical Research Excellence (COBRE) is to establish a multi-disciplinary translational research center focusing on cartilage and joint health and disease mechanisms and developing repair strategy. The projects encompass clinical, biological, and engineering research fields. Projects 1 and2 analyze how long bones are built up during skeletal development. Projects 3 and 4 examine how joint cartilage degenerates in adult joint diseases. Project 5 studies how to repair and re-build healthy cartilage joint. The investigators and mentors are selected from five departments in Rhode Island Hospital/Brown Medical School (Orthopaedics, Pediatrics, Emergency Medicine, Medicine, and Bioengineering). The junior investigators include three clinician/scientists and two basic research scientists. The mentors also include both clinician/scientists and basic research scientists. Each mentor is a Principal Investigator of multiple federal grants (NIH RO1 or VA). They will supervise junior investigator's research projects, serve as their role models, and mentor them to obtain federal research project grants. Our vision is, by establishing this research infrastructure, we will enable clinicians working side-by-side with basic research scientists, junior investigators with senior investigators, and biologists with bioengineers. This multi-disciplinary approach is absolutely necessary to develop translational strategies for prevention and treatment of skeletal joint diseases.