CARDIOVASCULAR CORE

心血管和肾脏并发症，包括动脉粥样硬化和血脂异常，糖尿病 心肌病、中风和肾脏疾病是糖尿病的主要发病率和死亡率。这个 小鼠的糖尿病并发症似乎与人类的大致相同。该计划的目的是 心血管病理生理学和并发症的核心(CPCC)是提供快速、全面和 在小鼠模型中准确筛查心血管疾病和糖尿病并发症。鼠标 此核心使用的表型测试模仿并可直接翻译为用于评估 糖尿病患者。核心服务包括评估a)心脏形态和功能，包括 形态、组织学和超声心动图；b)血管调节，包括静息测量血液 压力和对血管运动扰动的反应；c)运动能力和代谢功能；d) 综合肾功能；e)微血管功能；和f)心血管疾病的循环标志物 包括电解质、肾功能指数、糖化血红蛋白和血脂。的范围 CPCC进行的表型试验允许彻底调查该病毒的存在、与 和修改或改善心血管疾病，以及与以下相关的糖尿病并发症 在老鼠身上进行特定的基因操作。

Cardiovascular and renal complications, including atherosclerosis and lipid abnormalities, diabetic cardiomyopathy, stroke and renal disease, comprise the major morbidity and mortality in diabetes. The complications of diabetes mellitus in mice appear to be largely the same as in humans. The purpose of the Cardiovascular Pathophysiology and Complications Core (CPCC) is to provide rapid, comprehensive, and accurate screening for cardiovascular disease and complications of diabetes in mouse models. The mouse phenotyping tests used by this Core are modeled after and directly translatable to tests used to assess patients with diabetes. Core services include assessment of a) cardiac morphology and function, including morphology, histology and echocardiography; b) vascular regulation, including resting measurement of blood pressure and response to vasomotor perturbations; c) exercise capacity and metabolic function; d) comprehensive renal function; e) microvascular function; and f) circulating markers of cardiovascular disease including electrolytes, indices of renal function, glycated hemoglobin, and serum lipids. The range of phenotyping tests performed by the CPCC allows for thorough investigation of the presence, correlation with, and modification or amelioration of cardiovascular disease, as well as diabetic complications associated with specific genetic manipulations in the mouse.