Enhancing the Vascularization Properties of Skin Tissue

描述（由申请人提供）：迄今为止，还没有专门针对慢性伤口缺氧性质的生物治疗方案被开发和上市。虽然单个血管生成因子的施用可能刺激血管生成的某些方面，但促进血管形态和功能正常需要多种因子的同时表达。在这项II期研究中，我们提出对人类角化细胞细胞系进行基因修饰，以协调表达多种治疗因子的升高水平。Stratatech公司在人类角质形成细胞系专利的离体基因工程方面取得的进展，使其在完成这项工作方面处于独特的地位。如果成功，这项研究将最终导致改进治疗方法的发展和商业化，以促进慢性伤口和其他严重皮肤缺陷的愈合。

DESCRIPTION (provided by applicant): To date no biological treatment options specifically targeting the hypoxic nature of chronic wounds have been developed and marketed. While administration of individual angiogenic factors may stimulate some aspects of angiogenesis, the simultaneous expression of multiple factors is required to promote morphologically and functionally normal vessels. In this Phase II study, we propose to characterize a human keratinocyte cell line genetically-modified to coordinately express elevated levels of multiple therapeutic factors. Advances in ex vivo genetic engineering of a patented human keratinocyte cell line at Stratatech Corporation has made it uniquely positioned to complete this work. If successful, the proposed research will ultimately lead to the development and commercialization of improved treatments to promote the healing of chronic wounds and other severe skin defects.