NEW METHODS TO MEASURE AMIDE PROTON RELAXATION DISPERSIONS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 开发了一种新的脉冲序列，它可以在比以前的序列更高的灵敏度、更高的精度和更高的有效场下测量酰胺质子的T_1Rho弛豫。该序列将用于检测心肌肌钙蛋白C的微秒时间尺度动力学。此外，还将测量建立的N15弛豫离散度实验，以验证结果。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A new pulse sequence has been developed that allows the measurement of amide proton T1rho relaxation at higher sensitivity, higher accuracy and higher effective fields than previous sequences. The sequence will be used to detect micorsecond time scale dynamics in cardiac Troponin C. In comarison established N15 relaxation dispersion experiments will be measured as well to verify the results.