CONTROL OF MITOCHONDRIAL FUNCTION BY NITRIC OXIDE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 Heck博士感兴趣的是紫外线诱导的氧化应激作为致癌机制的机制。她一直在刻画内源性细胞光敏剂和抗氧化剂的特征，它们在保护细胞免受紫外线介导的毒性方面形成平衡。赫克博士发现，一氧化氮是紫外线作用的关键介质。她的研究重点是确定一氧化氮是否作为促氧化剂的抗氧化剂发挥作用。为此，她在BRC中积极开发和验证了一种一氧化氮自参照生物传感器。在BRC中，她一直在研究不同类型的细胞产生一氧化氮的特征。她还一直在研究过氧亚硝酸盐在调节细胞氧化应激中的作用，这是使用自参照氧生物传感器测量的。在与约书亚·格雷的合作中，她一直在研究高氧在调节细胞一氧化氮产生中的作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Dr. Heck is interested in mechanisms of oxidative stress induced by ultraviolet light as a mechanism of carcinogenesis. She has been characterizing endogenous cellular photosensitizers and antioxidants that form a balance in protecting cells from ultraviolet light-mediated toxicity. Dr. Heck has found that nitric oxide is a key mediator of the actions of ultraviolet light. Her research has focused on determining if nitric oxide functions as an anti-oxidant of a pro-oxidant. Towards this end she has been active in the BRC in developing and validating a nitric oxide self-referencing biosensor. In the BRC she has been characterizing nitric oxide production by a variety of cell types. She has also been investigating the role of peroxynitrite in mediating cellular oxidative stress as measured using a self-referencing oxygen biosensor. In collaboration with Joshua Gray, she has been investigating the role of hyperoxia in mediating cellular nitric oxide production.