MouseCyc: A Biochemical Pathway Database for the Mouse

描述（由申请人提供）：我们建议开发MouseCyc，这是一种小鼠生化途径基因组数据库，整合了小鼠基因表型、基因表达数据、功能注释和哺乳动物同源性的精心策划的信息，可从小鼠基因组信息学（MGI）数据库获得。拟议工作的结果将为科学界提供一个在生物化学和代谢过程背景下的小鼠遗传和基因组数据的视图。这一功能将进一步提高小鼠作为理解人类生物学和疾病过程的模型系统的价值。为了实现MouseCyc，我们将使用一个名为Pathway Tools的强大软件套件，该套件具有用于创建，管理和可视化生物体特定生化途径数据的组件。一旦MouseCyc实施，我们将使用已发表的科学文献、其他数据库以及（在适当情况下）主题专家的信息来整理小鼠的途径数据。将使用Pathway Tools软件开发工具包中包含的基于网络的数据查询和浏览功能访问MouseCyc。这些数据库还将作为其他途径表示和建模项目的精选小鼠途径数据的来源。我们将与Pathway Tools软件的开发人员合作，以实现支持基于策划基因同源性和保守同线性关系的人类和小鼠途径比较的机制。MouseCyc数据库将作为一个可公开访问的互联网资源，科学界将使用该数据库在生物化学和代谢过程的背景下分析小鼠遗传和基因组数据。数据库中的数据管理和表示的优先权将给予实验室小鼠中的那些基因，这些基因在人类中具有已知与疾病有关的对应物。MouseCyc的可视化和查询接口将进一步提高小鼠作为理解人类生物学和疾病过程的模型系统的价值。

DESCRIPTION (provided by applicant): We propose to develop MouseCyc, a biochemical pathway genome database for the mouse that is integrated with well-curated information on phenotypes, gene expression data, functional annotations, and mammalian homology for mouse genes that is available from the Mouse Genome Informatics (MGI) database. The results of the proposed work will provide the scientific community a view of mouse genetic and genomic data in the context of biochemical and metabolic processes. This functionality will further enhance the value of the mouse as a model system for understanding human biology and disease processes. To implement MouseCyc we will use a robust software suite called Pathway Tools that has components for the creation, curation, and visualization of organism-specific biochemical pathway data. Once MouseCyc is implemented, we will curate pathway data for the mouse using information from the published scientific literature, other databases and, where appropriate, subject matter experts. Access to MouseCyc will be provided using web-based data query and browsing capabilities that are included in the Pathway Tools software development kit. The databases will also serve as a source of curated mouse pathway data for other pathway representation and modeling projects. We will work collaboratively with the developers of the Pathway Tools software to implement mechanisms to support comparisons of human and mouse pathways based on curated gene homology and conserved synteny relationships. Relevance to Public Health The MouseCyc database will serve as a publicly accessible internet resource that the scientific community will use to analyze mouse genetic and genomic data in the context of biochemical and metabolic processes. Priority for data curation and representation in the database will be given to those genes in the laboratory mouse that have counterparts in humans that are known to be involved in disease. The visualization and query interfaces for MouseCyc will further enhance the value of the mouse as a model system for understanding human biology and disease processes.