NEW CHEMISTRY FOR MULTIPROTEIN COMPLEXES

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 柯达德克博士实验室的一个基本目标是设计与任何所需蛋白质高度亲和力和特异性结合的分子。这种试剂的最终应用将是建造先进的诊断设备，用于基于蛋白质的模式识别。如果可以为许多蛋白质确定特定的配体，那么签名似乎就有可能被识别并用于诊断。可以设计低分子质量的人造抗体，但一个重要的问题是检测与目标蛋白的结合事件。这个应用程序测试了为此目的使用MRI的可行性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A fundamental goal of Dr. Kodadek's lab is to design molecules that bind with high affinity and specificity to any desired protein. The ultimate applicatioin of such reagents would be in the construciton of advanced diagnostic devices that would be employed for protein-based pattern recognition. If specific ligands could be identified for many proteins, then it seems likely that signatures could be recognized and used diagnosticlly. Low molecular weight ""artificial"" antibodies can be designed, but an important problem is detecting the binding event with the target protein. This application tests the feasibility of using MRI for this purpose.