MULTI-DISCIPLINARY APPROACHES FOR PRECLINICAL RESEARCH IN PARKINSONS DISEASE

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 当纹状体多巴胺水平降低50%且黑质内80%的多巴胺能（DA）神经元变性时，PD的临床症状出现（Marsden 1990）。 路易体形成是PD神经病理学的标志性特征，在包括黑质在内的脑的几个区域中发现。 在路易小体中发现[α]-突触核蛋白（[α]-SYN）的聚集体（Spillantini et al. 1997; Wakabayashi et al. 1997），这表明[α]-SYN在PD中的作用。 加州大学圣地亚哥分校的Masliah博士和同事们是第一批在研究阿尔茨海默病时描述[alpha]-SYN的人之一s病（Iwai等1995; Masliah等1996）。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The presentation of clinical symptoms of PD occurs when striatal dopamine levels decrease by 50% and 80% of dopaminergic (DA) neurons within the substantia nigra have degenerated (Marsden 1990). Lewy body formations, a hallmark feature of PD neuropathology, are found in several areas of the brain including the substantia nigra. Aggregates of [alpha]-synuclein ([alpha]-SYN) are found within Lewy Bodies (Spillantini et al. 1997; Wakabayashi et al. 1997), which suggests a role for [alpha]-SYN in PD. Dr. Masliah and colleages at UC San Diego was among the first to characterize [alpha]-SYN while working on Alzheimers disease (Iwai et al. 1995; Masliah et al. 1996).