MECHANISMS OF BIOORGANIC AND ORGANOMETALLIC CYCLIZATION REACTIONS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 本文提出的CHE030089N的研究重点是应用现代量子化学方法来阐明用于多环有机分子合成和生物合成的有机化学反应的分子机理。在本授权期内，我们将集中于五个子项目：(项目1，上一批授权期继续)阳离子促进的生物合成多环化反应导致含有梯烷的细菌脂类，(项目2，上一批授权期继续)涉及萜类天然产物生物合成的阳离子促进的多环化反应，(项目3，上一批授权期继续)涉及聚醚天然产物生物合成的酸和碱促进的聚环氧基环化，(项目4；新的)用于合成复杂杂环的周环级联反应，和(项目5；从上一批赠款期间的相关项目扩展而来)镍和钯促进的Sigmatroic重排。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The focus of the research proposed herein, a renewal of CHE030089N, is to apply modern quantum chemical methods to the elucidation of molecular mechanisms of organic chemical reactions that are used in the synthesis and biosynthesis of polycyclic organic molecules. During this award period, we will concentrate on five subprojects: (project 1; continued from the previous grant period) cation-promoted biosynthetic polycyclization reactions leading to ladderane-containing bacterial lipids, (project 2; continued from the previous grant period) cation-promoted polycyclization reactions involved in biosyntheses of terpene natural products, (project 3; continued from the previous grant period) acid and base-promoted polyepoxide cyclizations involved in the biosynthesis of polyether natural products, (project 4; new) pericyclic cascade reactions used in the synthesis of complex heterocycles, and (project 5; expanded from the related project from the previous grant period) Ni and Pd-promoted sigmatropic rearrangements.