NON-DIFFUSION MAPPING OF WHITE MATTER PROTONS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究的目标是开发一种方法来可视化大脑中的白质区域，这与DTI或扩散张量成像是结合在一起的，但又是分开的。由于DTI可能有丢失，这种映射白质质子池的方法提供了第二种显示白质位置的方法，可以将其叠加到DTI图上，以更好地了解白质图的结构。这一汇集序列使用快速磁共振成像来增强靠近或邻近白质质子的水氢质子。序列已经写入，初步数据显示CELAR白质结构与DTI所见不同。这种方法被称为WIMP，或白色物质质子，使用螺旋序列，可以扩展到单激发或多激发方法。这种方法的一个优点是它最小化了高场下的SAR值，这对于像我们的7T全身系统这样的高场研究来说是至关重要的。在没有MT效应或预脉冲的情况下，可以看到结合水组分。它展示了真正的质子稀释原理。结果给出了出色的灰白质显着性，并提供了大量关于结合水组分的新信息。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this research is to develop ways of visualizing white matter regions in the brain which is in conjunction but separate from DTI or diffusion tensor imaging. Since DTI may have drop-outs, this method of mapping pooling of white matter protons provides a secondary means of showing where the white matter is which can be overlaid onto DTI maps for better understanding of the structure of the white matter maps. This pooling sequence uses rapid MRI for enhancing water hydrogen protons which are near or adjacent to white matter protons. The sequence has been written and preliminary data shows celar white matter structures different from those seen from DTI. The method, called WIMP, or White Matter Protons uses a spiral sequence and can be expanded to single- or multi-shot methods. One advantage of the method is that it minimizes the SAR values at high-fields which is crucial for studies at very high fields such as our 7T whole-body system. The bound water fractions can be seen without MT effects or prepulses. It displays true proton dilution principles. The results give excellent gray-white matter conspicuity with a wealth of new information regarding the bound water fractions.