Mental Retardation and Developmental Disabilities Research Centers 2006

描述（由申请人提供）：该中心赠款要求为七个核心设施提供资金，以支持在精神发育迟滞和发育障碍研究中的广泛研究计划。七个核心设施是：行政，蛋白质组学，细胞神经科学，成像，基因操作，分子遗传学和细胞分选。这些核心经历了重大发展，并支持了123个研究项目和73名调查人员。该研究是在两个方案领域（神经科学和遗传学）。在神经科学中，有两个主要项目（基础神经科学和临床/转化神经科学）。基本神经科学计划由中心主任Michael Greenberg博士指导，由47名研究人员组成，他们的研究工作涵盖了分子神经科学和系统神经生物学的广泛交叉研究。基础神经科学的一个研究项目，在这项资助中被提议为“新计划”，解决了“GTdR调节酶ephexin 5在突触形成和树突棘发育中的功能”（Mustafa Sahin，M.D.，Ph.D.）。神经科学的第二个主要项目，即，由Scott Pomeroy博士指导的临床/转化神经科学包括15名研究人员，他们的研究工作包括神经肿瘤学，脑损伤，新生儿脑行为和脑发育，人类视觉发育，HIV，心脏病，手术和发育中的大脑，大脑发育，神经认知发育，发育神经心理学和学习障碍的体内研究等领域。以及内源性和外源性pxins和大脑发育。这些临床研究领域与MRDDRC的基础研究相互交叉。在遗传学方面，由Louis Kunkel博士指导，11名研究人员正在研究神经肌肉疾病和人类大脑皮层发育的分子遗传学，遗传疾病的分子基础，视网膜发育和退行性疾病，信号转导，肌肉干细胞，复杂性状的遗传学和遗传性肌肉骨骼疾病。该MRDDRC研究的多学科方法包括遗传学和神经科学中的各种基础科学学科，以及神经病学，儿科学，新生儿学，传染病，内分泌学，代谢，遗传学，心脏病学，神经病理学，眼科学，精神病学和心理学的临床科学领域。研究项目位于超过142，000平方米。英尺在儿童医院的两座研究大楼和哈佛-朗伍德医疗区的其他几个设施中。

DESCRIPTION (Provided by applicant): This Center grant requests funding for seven Core facilities to support a broadly-based research program in the study of mental retardation and developmental disabilities. The seven Core facilities are: Administrative, Proteomics, Cellular Neuroscience, Imaging, Gene Manipulation, Molecular Genetics, and Cell Sorter. The cores have undergone major development and support 123 research projects and 73 investigators. The research is in two programmatic areas (Neuroscience and Genetics). In Neuroscience, there are two major programs (Basic Neuroscience and Clinical/Translational Neuroscience). The Basic Neuroscience Program, directed by the Center Director, Dr. Michael Greenberg, consists of 47 investigators whose research efforts span a broad spectrum of interdigitated research in molecular neuroscience and systems neurobiology. A research project in Basic Neuroscience, proposed in this grant as a "New Program," addresses " the function of the GTPase regulatory enzyme, ephexin5, in synapse formation and dendritic spine development" (Mustafa Sahin, M.D., Ph.D.). A second major program in Neuroscience, i.e., Clinical/Translational Neuroscience, directed by Dr. Scott Pomeroy, includes 15 investigators whose research efforts include such areas as neuro-oncology, brain injury, brain behavior and brain development in neonates, human visual development, HIV, heart disease, surgery, and the developing brain, in vivo studies of brain development, neurocognitive development, developmental neuropsychology and learning disabilities, and endogenous and exogenous pxins and brain development. These areas of clinical research interdigitate with the basic research in the MRDDRC. In Genetics, directed by Dr. Louis Kunkel, 11 investigators are studying the molecular genetics of neuromuscular disease and human cerebral cortical development, the molecular basis of genetic disorders, retinal development and degenerative disorders, signal transduction, muscle stem cells, the genetics of complex traits and inherited musculoskeletal disorders. The multidisciplinary approaches to the research of this MRDDRC include the various basic science disciplines within Genetics and Neuroscience, and the clinical science fields of Neurology, Pediatrics, Neonatology, Infectious Disease, Endocrinology, Metabolism, Genetics, Cardiology, Neuropathology, Ophthalmology, Psychiatry, and Psychology. The research programs are housed in over 142,000 sq. ft. in two research buildings at Children's Hospital and several other facilities within the Harvard-Longwood Medical Area.