ANAL DYSPLASIA AND ANAL HPV IN HIV-POSITIVE AND HIV-NEGATIVE MEN

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本研究的目的是：确定在高效抗逆转录病毒治疗（HAART）时代，与HIV阴性对照相比，HIV阳性男性中肛门鳞状上皮内病变（ASIL）的患病率;检查免疫学参数、报告的性行为、种族、HIV感染和HPV感染与患病ASIL的相关性;并比较有肛交史的HIV阳性男性、无肛交史的HIV阳性男性和HIV阴性对照组之间肛门HPV感染的患病率和持续性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The aims of this study are: to define the prevalence of anal squamous intraepithelial lesions (ASIl) among HIV+ men in the era of highly active anti-retroviral therapy (HAART) as compared to HIV-negative controls; to examine the association of immunologic parameters, reported sexual behavior, race, HIV infection and HPV infection on prevalent ASIL; and to compare the prevalence and persistence of anal HPV infection between HIV+ men with a history of receptive anal intercourse, HIV+ men without this history, and HIV-negative controls.