CORE--RESEARCH SERVICES

描述(由申请人提供)： 研究服务核心为该计划中的所有五个项目提供基本支持。麻省理工学院生理系的核心设施是从最初的计划项目组发展而来的。随着该部的发展，调查人员发现，这些设施对他们的研究越来越重要。目前的核心设施部分由该部和非PPG研究拨款支持，但研究服务核心的最大单一用户和支持者仍然是该计划。PPG对这些核心设施的持续财政支持对于本计划中提出的工作至关重要，没有这些核心，本申请中提出的研究就无法进行。该计划的研究服务核心在前一次资助期间扩大了范围和规模，增加了组织学、显微镜和图像处理方面的新活动。目前有11名人员在研究服务核心部门工作，每个人都在支持生理学系研究基础设施的广泛活动中拥有丰富的经验。这些工作人员被分配到一个或多个支持小组，计算机、分析、动物建模、显微镜、机械和电子设备以及仪器服务。根据这些小组活动的交叉数量，我们现在发现，在安德鲁·S·格林博士的监督下，将他们的努力统一到一个核心中更有成效。在这些自然划分的基础上，研究服务核心在计划项目中提供7项主要职能：计算机支持、分析和统计咨询、慢性动物监测、显微镜和图像处理、定制机器和电子制造、仪器服务以及鼠群维护。

DESCRIPTION (provided by applicant): The Research Services Core provides basic support for all five of the projects in this Program. The Core facilities in the Department of Physiology at MCW evolved from the original Program Project group. As the Department has grown investigators have found these facilities to be increasingly essential to their research. The current core facilities are supported in part by the Department and non-PPG research grants, yet the single largest user and supporter of the Research Services Core remains this program. The continued financial support of these core facilities by the PPG is essential for the work proposed in this Program, without these cores, the research proposed in this application could not be conducted. The Research Services Core of this program has expanded in both scope and size during the previous grant period with the addition of new activities in Histology, Microscopy, and Image Processing. Eleven individuals currently staff the Research Services Core, each with significant experience in a broad range of activities that support the research infrastructure within the Department of Physiology. This staff is divided among one or more support groups, computer, analytical, animal modeling, microscopy, machine and electronics, and instrument service. Based on the amount of crossover in the activities of these groups we have now found it more productive to unify their efforts into one core under the supervision of Dr. Andrew S. Greene. Based on these natural divisions, the Research Services Core serves 7 main functions within the program project; computer support, analytical and statistical consultation, chronic animal monitoring, microscopy and image processing, custom machine and electronic fabrication, instrument service, and rat colony maintenance.