Modulation of Cytokine Responses to Improve Transplant Outcome.

骨髓移植仍然是血液系统恶性肿瘤治疗的主要手段。这种疗效是由移植的供体免疫系统介导的，该免疫系统排斥受体恶性肿瘤。然而，该程序受到其严重副作用的限制，即所谓的移植物抗宿主病。本申请寻求在免疫学和临床水平上更好地理解这两个过程，目的是将两者分开，以便更多的患者可以治愈白血病。

Bone marrow transplantation remains a mainstay of curative therapy for haematological malignancies. This curative effect is mediated by the transplanted donor immune system which rejects the recipient malignancy. However, the procedure is limited by its serious side effect, known as graft-versus-host disease. This application seeks to better understand these two processes at both an immunological and clinical level with the aim of separating the two so that more patients may be cured of leukaemia.