Peptide Core

核心C：肽-肽核心的总体使命是提供所需的资源和服务 选择、筛选、测序、合成、标记和分析用于初级和任务的肽 优先结合和检测胃肠道发育异常的特定项目。钟 Owyang博士是这个拟议的NTR研究中心的核心C：肽的主任。欧阳博士也是 私家侦探密歇根大学胃肠病肽研究核心中心的NIH/NIDDK 消化疾病中心的使命是研究功能特性和信号传导 肠肽的机制。他为指导肽结合研究提供了丰富的经验 与肿瘤转化相关的细胞表面受体的相互作用和靶点鉴定 消化道Henriette Remmer博士是该核心的联合主任。她也是蛋白质的主任 密歇根大学的结构核心设施，并在肽技术方面具有重要经验 合成和蛋白质结构分析。Remmer博士将作为一名 关于肽作为探针的开发、合成和分析所有步骤的咨询资源 消化道癌前病变粘膜的检测。Henriette Remmer博士是该项目的联合主任， 核心她也是密歇根大学蛋白质结构核心设施的主任， 在多肽合成技术和蛋白质结构分析方面有丰富的经验。雷默医生会 可供网络调查人员作为关于所有发展步骤的咨询资源， 合成和分析肽作为检测消化道中癌前粘膜的探针。 Xiaoju（乔治）Wang博士也是NTR研究中心核心C：肽的联合主任。G博士 Wang在噬菌体展示技术方面有着丰富的经验，特别是在采用高通量 噬菌体表位微阵列和多重蛋白/表位微阵列。这些资源将是宝贵的 进行肽筛选，以确定后续临床使用的最佳候选物，并将可用于 网络中的所有调查员。

Core C: Peptides - The overall mission of the Peptide Core is to provide the resources and services needed to select, screen, sequence, synthesize, label, and analyze the peptides to be used in the Primary and Task Specific Projects for preferential binding and detection of dysplasia in the gastrointestinal tract. Chung Owyang, MD is the Director of Core C: Peptides for this proposed NTR Research Center. Dr. Owyang is also the P.I. of the Gastroenterology Peptide Research Core Center at the University of Michigan, an NIH/NIDDK funded Digestive Disease Center whose mission is to investigate the functional properties and signaling mechanisms of gut peptides. He provides a wealth of experience for guiding research in the peptide binding interactions and target identification of cell surface receptors associated with neoplastic transformation in the digestive tract. Henriette Remmer, PhD, is the Co-Director of this Core. She is also the Director of the Protein Structure Core Facility at the University of Michigan, and has significant experience in techniques of peptide synthesis and protein structure analysis. Dr. Remmer will be available to the network investigators as a resource for consultation regarding all steps of development, synthesis, and analysis of peptides as probes for the detection of pre-malignant mucosa in the digestive tract. Henriette Remmer, PhD, is the Co-Director of this Core. She is also the Director of the Protein Structure Core Facility at the University of Michigan, and has significant experience in techniques of peptide synthesis and protein structure analysis. Dr. Remmer will be available to the network investigators as a resource for consultation regarding all steps of development, synthesis, and analysis of peptides as probes for the detection of pre-malignant mucosa in the digestive tract. Xiaoju (George) Wang, Ph.D is also a Co-Director for Core C: Peptides for this NTR Research Center. Dr. G Wang has significant experience in techniques of phage display, in particular with employing high-throughput phage epitope microarrays and multiplexed protein/epitope microarrays. These resources will be valuable for performing peptide screening to identify optimal candidates for subsequent clinical use, and will be available to all of the investigators in the network.