AIRWAY AND IMMUNE RESPONSE TO INHALED ENDOTOXIN AND DIESEL EXHAUST PARTICLES

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 本研究的目的是评估柴油机尾气颗粒物(DEP)和内毒素对呼吸道功能的潜在相互作用。内毒素是由环境中的细菌产生的。它存在于我们呼吸的大部分空气中，在农场的粉尘中发现的浓度更高。吸入内毒素已被证明会引起类似哮喘的症状，我们正在调查在接触柴油废气颗粒的同时暴露内毒素是否会导致更多的呼吸道炎症。通过了解DEP和内毒素如何影响肺部，我们希望对农场工人和哮喘患者的健康问题有更好的了解。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this research study is to evaluate potential interactions between diesel exhaust particles (DEP) and endotoxin on airway function. Endotoxin is made by bacteria in the environment. It is present in most of the air that we breathe, and is found in higher concentrations in dust from farms. Inhaling endotoxin has been shown to cause symptoms similar to asthma, and we are investigating whether endotoxin exposure at the same time as exposure to diesel exhaust particles leads to more inflammation of the airway. By learning about how DEP and endotoxin affect the lungs, we hope to gain a better understanding of the health problems of farm workers as well as persons with asthma.