PROSPECTIVE LUPUS COHORT STUDY OF DISEASE ACTIVITY AND PREDICTORS OF MORBIDITY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 JHH的狼疮中心位于独特的位置，通过对大量SLE患者的前瞻性随访来解决临床研究问题。在佩里博士第一次获奖期间，讨论的问题包括与抗磷脂抗体相关的未来血栓形成和冠状动脉疾病的风险，常规心血管危险因素，以及泼尼松的使用。狼疮队列现已由美国国立卫生研究院退还。RO-1的具体目标虽然是第一个奖项工作的延续，但现在包括了对疾病活动和残疾的重视。持续的疾病活动使患者暴露在皮质类固醇的副作用中。超过一半的患者遭受永久性器官损伤。确定疾病活动的预测因素应有助于减少不必要的皮质类固醇治疗，并允许在需要时尽早进行治疗。 每当患者有预定的就诊时间，就会额外抽取三到十汤匙的血液来检测疾病活动性和凝血情况。此外，还完成了肌肉压痛(纤维肌痛)的记录。此外，每年都会联系患者几次，这样我们就可以确定器官损伤和残疾的其他风险因素(通过使用问卷)。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Lupus Center at JHH is uniquely situated to address clinical research issues through prospective follow-up of a large number of SLE patients. During Dr. Petri's FIRST award, issues addressed included the risk of future thrombosis and coronary artery disease associated with antiphospholipid antibodies, routine cardiovascular risk factors, and prednisone use. The Lupus Cohort has now been refunded by the NIH. The specific aims of the RO-1, although a continuation of the FIRST award work, now include an emphasis on disease activity and disability. Ongoing disease activity exposes patients to the side effects of corticosteroids. Over one-half of patients sustain permanent organ damage. Determination of predictors of disease activity should help to reduce unneeded corticosteroid treatment and allow institution of earlier treatment when it is needed. Whenever a patient has a scheduled visit, three to ten extra tablespoons of blood are drawn to test for disease activity and clotting. A record of tender muscles (fibromyalgia) is also completed. In addition, several times a year, patients are contacted so that we can determine other risk factors for organ damage and disability (through the use of questionnaires).