GNRH WEBSITE (U-54 SUPPLEMENT)

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 GnRH网站项目继续在实现其目标方面取得进展，该目标是提供一个基于网络的界面，以了解GnRH途径和相关的临床和研究资源。我们通过加入Wiki界面（http：//www.wiki.org/）大大扩展了网站的功能，用户不仅可以查看GnRH基因和受体家族信息，还可以添加和评论这些信息。我们正在积极评估GnRH和更广泛的科学界将如何使用此Wiki功能（例如http：//www.wikipedia.org/）。 我们已经建立了一个公开版的网站（http：//iGnRHnet.ohsu.edu/）。我们将继续与ONPRC和生殖研究人员一起反复评估和改进功能。该网站提供了一个关于GnRH基因和受体家族的信息数据库，包括转录本、组织和发育表达、胚胎发生等。该网站还包含一个GnRH的交互式信号传导途径，该途径具有元件间的链接，并附有支持所描述的相互作用的参考文献，沿着用于查看这些模型的软件，有助于直观地突出模型版本之间的差异。我们继续改进该模型，以包括下丘脑GnRH分泌的控制和调节GnRH神经元活性的其他机制（例如受体激活等）。 公共网站继续设在OHSU高级计算中心（http：acc.ohsu.edu），并支持连续操作和备份。在本进度报告所涵盖的期间，该网站没有停机时间。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The GnRH Website project continues to make progress in accomplishing its goal of delivering a web-based interface to GnRH pathway and related clinical and research resources. We have significantly extended the functionality of the site by incorporating a Wiki interface (http://www.wiki.org/) which allows users to not only view GnRH gene and receptor family information, they can also now add to and comment on that information. We are actively evaluating how this Wiki functionality (e.g. http://www.wikipedia.org/) will be used by the GnRH and broader scientific communities. We have deployed a public version of the web site (http://iGnRHnet.ohsu.edu/). We continue to iteratively evaluate and improve the functionality with ONPRC and reproduction researchers. The site features a database of information on the GnRH gene and receptor families, including on transcripts, tissue and developmental expression, phylogeny, etc. The site also contains an interactive signaling pathway for GnRH with inter-element links annotated with literature references supporting the depicted interactions, along with software for the viewing of these models that helps visually highlight differences between model versions. We continue to improve the model to include the control of hypothalamic GnRH secretion and other mechanisms regulating GnRH neuronal activity (e.g. receptor activation, etc.). The public web site continues to be housed in the OHSU Advanced Computing Center (http://acc.ohsu.edu), and supported for continuous operations and backup. The site has had no down-time during the period covered by this progress report.