Impact of BDNF Genotypes and Stress on Learning and Brain Development

说明(申请人提供)：行政和数据管理核心(戈尔行政管理)对整个中心(项目I、II、III)的运作至关重要。中心将管理和维护中心的数据，促进项目之间的科学互动，并促进中心的教育倡议。ADM核心的主要活动之一是为中心维护数据库(行为、遗传和成像)，并为项目1、11和III提供备份和IT服务。它将作为中心的数据通道，接收处理后的数据(成像和行为)，维护这些数据，并使其可用于所有其他核心，包括用于数据分析的统计遗传学核心。ADM核心代表了一个单一的管道，负责处理人类DNA，并通过统一的识别号指示哪些受试者具有所需的等位基因，应该就项目I和II的成像部分联系。这种方法使数据能够以符合HIPAA的科学公正和可靠的方式收集和维护。行政管理核心将协调各中心之间的互动，包括在纽约举行的PIS项目年度会议和两年一次的中心咨询委员会会议，会上将审查项目进展和成果，并讨论未来计划。核心中心还将维护中心的网站www.sacklerInstitute te.org/cornell/。与中心有关的出版物将按照现行出版标准提供下载。工具和分析也将在这个网站上提供，所有项目教职员工和研究员的链接也将提供。除了这些支持职能外，行政管理核心的最后一项重要职责将是协调和监督与中心教育倡议有关的活动。对中心的研究和方法感兴趣的个人(例如研究生、博士后研究员、研究助理)将通过参加中心的年度会议和培训研讨会以及通过中心支持的研究的直接合作来接受中心支持的教育。此外，还将通过与威尔·康奈尔医学院的四个培训项目(神经科学研究生项目、三机构医学博士、儿科住院医师项目和精神病学住院医师项目)的互动，促进教育活动的开展。最后，ADM核心将负责协调Sackler夏季研究所的活动，该研究所提供关于中心方法的培训，包括神经成像、遗传学和动物行为模型。

DESCRIPTION (as provided by applicant): The Administrative and Data Management Core (ADM Gore) is crucial to the functioning of the entire Center (Projects I, II, III). The Core will manage and maintain Center data, facilitate scientific interactions among projects, and promote the educational initiatives of the Center. One of the primary activities of the ADM core is database maintenance (behavioral, genetic, and imaging) for the Center, as well as providing back-up and IT services to Projects 1,11, & III. It will serve as a data conduit for the Center, receiving processed data (imaging and behavioral), maintaining it, and making it available for all other cores, including the Statistical Genetics Core for data analysis. The ADM Core represents a single pipeline that is responsible for processing human DNA and indicating, via universal identification number, which subjects have the desired alleles and should be contacted for the imaging portion of Projects I & II. This approach enables data to be collected and maintained in a scientifically-unbiased and HIPAA-compliant way that is cost effective and reliable. The ADM core will coordinate Center interactions, including the Annual Conference of the Project Pis and biennial Center Advisory Board in New York, at which project progress and results will be reviewed and future plans discussed. The Core will also maintain the Center's website www.sacklerinstitute.org/Cornell/. Center-related publications will be made available for download in compliance with current publishing standards. Tools and assays will also be made available on this site as will links to all project faculty and fellows. In addition to these support functions, the final critical responsibility of the ADM Core will be to coordinate and oversee activities relating to the Center's Educational Initiative. Individuals interested in the research and methods of the Center (e.g., graduate students, postdoctoral fellows, research assistants) will receive Center supported education through attendance of annual Center meetings and training workshops and through direct collaboration on Center supported research. Additionally, educational initiatives will be fostered through interactions with four training programs at the Weill Cornell Medical College (the Neuroscience Graduate Program, the Tri-lnstitutional M.D., Ph.D., the Pediatric Residency Program, and the Psychiatric Residency Program). Finally, the ADM Core will be responsible for coordinating the activities of the Sackler Summer Institute that provides training on the methods of the Center, including neuroimaging, genetics, and animal models of behavior.