VALIDATING VIL-6 AS A TARGET FOR KSHV-ASSOCIATED DISEASE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 对猕猴的初步研究表明，与单独感染SIV的猕猴相比，实验感染SIV和恒河猴人类疱疹病毒8型同源物(RhHHV8)的猕猴会出现B细胞增生。与HHV8/Kaposi的肉瘤相关疱疹病毒(KSHV)一样，RhHHV8编码一种白细胞介素6(IL-6)同源物。HHV8/KSHV中的病毒IL-6同源物被认为是Kaposi肉瘤和艾滋病患者中感染HHV8/KSHV的B细胞来源的恶性肿瘤(称为体腔淋巴瘤或原发渗出性淋巴瘤)所必需的生长因子。这项研究的长期目标旨在评估在SIV感染的背景下，RhHHV8 IL-6同源物在病毒介导的B细胞增殖中的作用。这些研究的结果应该有助于阐明VIL-6在病毒感染中的作用，并为未来伽马-2疱疹病毒诱导的恶性肿瘤的诊断和治疗提供新的见解。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Preliminary studies in rhesus macaques reveal that macaques experimentally infected with the simian immunodeficiency virus (SIV) and a rhesus human herpesvirus 8 homologue (RhHHV8) develop B cell hyperplasia compared to macaques infected with SIV alone. The RhHHV8, like HHV8/Kaposi's sarcoma-associated herpesvirus (KSHV), encodes an interleukin-6 (IL-6) homologue. The viral IL-6 homologue in HHV8/KSHV is thought to be a necessary growth factor for Kaposi's sarcoma and the B cell-derived malignancy referred to as body cavity based lymphomas or primary effusion lymphoma in AIDS patients also infected with HHV8/KSHV. The long-term objectives of this study aim to evaluate the role of the RhHHV8 IL-6 homologue in viral-mediated B cell hyperplasia in the context of an SIV infection. The results from these studies should help elucidate the role of the vIL-6 in virus infection and provide new insights into the future development of diagnostics and therapies for gamma-2 herpesvirus-induced malignancies.