FACTORS UNDERLYING AGGRESSIVE BEHAVIOR IN MACAQUES

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 随着暴力行为比率的上升，更多的研究集中在攻击性及其相关特征的生理和遗传基础上。与攻击性有关的一个因素是5-羟色胺能系统。5-羟色胺缺乏被发现与攻击率和相关特征的增加有关，例如人类和其他动物的冲动行为。一种调节5-羟色胺的基因是5-羟色胺转运蛋白基因(5-HTT)。第二个调节5-羟色胺的基因是单胺氧化酶A(MAO-A)，它也可能在攻击性中起作用。虽然有相当多的证据支持这些基因与攻击性行为之间的关联，但其他研究未能复制这些发现。或者，非人类灵长类动物可能会提供一个很好的模型，来研究这些基因在攻击性和相关行为的表达中可能扮演的角色，以及识别可能与基因相互作用的环境因素，以影响行为结果。该项目的主要目标是检查一群半自由生活的日本猕猴的行为和生理与攻击性的相关性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. As rates of violent behavior rise, more work is focusing on physiological and genetic underpinnings of aggression and associated traits. One factor that was associated with aggression is the serotonergic system. Serotonin deficiencies have been found to correlate with increased rates of aggression and related traits, such as impulsive behavior in humans and other animals. One gene found to regulate serotonin is the serotonin transporter gene (5-HTT). A second gene that serves to regulate serotonin, and may also play a role in aggression, is monoamine oxidase A (MAO A). While there is considerable evidence supporting the association between these genes and aggressive behavior, other studies failed to replicate these findings. Alternatively, nonhuman primates may provide an excellent model for examining the role that these genes may play in the expression of aggression and related behaviors, as well as identifying environmental factors that may interact with genotype to influence behavioral outcome. The main goal of the project is to examine behavioral and physiological correlates to aggression in a group of semi-free living Japanese macaques.