FACTORS UNDERLYING ALOPECIA IN RHESUS MACAQUES

恒河猴脱发的因素

• 批准号: 8357843
• 负责人: Kristine Coleman
• 金额: $ 1.82万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357843
• 关键词: Adult; Alopecia; Animals; Behavior; Behavioral; Biological Assay; Etiology; Female; Funding; Grant; Grooming; Hair; Hydrocortisone; Life; Macaca mulatta; Monkeys; National Center for Research Resources; Pattern; Primates; Principal Investigator; Research; Research Infrastructure; Resources; Sampling; Shelter facility; Source; United States National Institutes of Health; cost; nonhuman primate; research facility

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Hair loss, or alopecia, is a common problem among nonhuman primates and other animals in research facilities. Alopecia is recognized as a potential indicator of compromised well being, yet there are surprisingly few studies investigating potential etiologies and treatments for this condition. This study examined some potential behavioral factors that may correlate with alopecia in female monkeys. We assessed both alopecia and behavior in 16 adult female rhesus macaques living in one of two separate outdoor environmentally controlled shelter houses. To assess alopecia, we took photos of each of the monkeys during their annual physical exams. We also obtained a hair sample, which will be assayed for cortisol content. We also assessed behavior by taking focal observations on the animals. We found that alopecia pattern was associated with hair pulling behavior. Only animals with a patchy pattern of alopecia engaged in hair pulling behavior (typically as the recipient). There were no differences in grooming or other behaviors among animals with the three patterns of alopecia. This finding suggests that self-epilating behaviors such as hair pulling may be associated with specific phenotypic patterns.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 脱发或脱发是非人类灵长类动物和研究机构中其他动物的常见问题。脱发被认为是健康受损的潜在指标，但令人惊讶的是，很少有研究调查这种疾病的潜在病因和治疗方法。 本研究探讨了一些可能与雌性猴子脱发相关的潜在行为因素。 我们评估了16只成年雌性恒河猴的脱发和行为，这些猕猴生活在两个独立的室外环境控制庇护所中的一个。 为了评估脱发，我们在每只猴子的年度体检期间拍摄了它们的照片。我们还获得了一个头发样本，这将是测定皮质醇含量。我们还通过对动物进行重点观察来评估行为。 我们发现，脱发的模式与头发拉行为。只有斑秃的动物才会有拔毛行为（通常是作为受体）。 三种脱毛模式的动物在梳理毛发或其他行为方面没有差异。这一发现表明，自我脱毛行为，如头发拉可能与特定的表型模式。