RODENT MODELS CORE

引言 啮齿动物模型核心为转基因和非转基因动物的产生和鉴定提供了技术支持 小鼠的敲除品系，可以共享的昂贵的小鼠和大鼠行为设备 在几个研究人员中，以及在MRDD小鼠和大鼠模型的行为表型方面的专业知识 以及与中枢神经系统相关的疾病。此外，核心负责护理、喂养和记录保存 与MRDDRC项目对小鼠和大鼠的使用和特定啮齿动物的维护有关 发育模型、发育障碍和神经退行性疾病。这一核心一直是 在本项目期间更名，反映了其重点的加强和大量新的专门知识 以及在过去五年中增加的服务，以应对不断增长和不断变化的 这是为了满足解甲返乡研究中心调查人员的需要，并为解甲返乡研究中心不断演变的科学议程作出贡献。 分配给该核心的空间正在进行重大翻新，截至2005年1月，导致 临时将所有动物转移到校园内的其他设施，并将看守人员重新分配到 那些设施。在进行翻新期间，核心服务在这些备用地点继续不间断 地点。对啮齿动物模型核心的描述包括对该核心如何运行的解释 当动物在2007年回来时，新培训的工作人员将操作这个特殊的和完全现代化的 为使用啮齿动物模型的MRDDRC调查人员提供多样化的科学需求的设施。在描述中 下面，现在时态用来描绘暂时不间断的资源和服务 翻新期间的地点，过去式用来指代翻修前的改进，以及 将来时用来指在#年完成翻修后将提供的新的核心服务 2007年。因此，对啮齿动物模型核心的描述反映了过去成就的优势，如 以及对未来成就的承诺。

INTRODUCTION The Rodent Models Core provides technical support for the generation and characterization of transgenic and knockout strains of mice, access to expensive behavioral equipment for mice and rats that can be shared among several investigators, and expertise in the behavioral phenotyping of mouse and rat models of MRDD and related disorders of the CNS. In addition, the Core is responsible for the care, feeding, and recordkeeping related to the use of mice and rats by MRDDRC projects and the maintenance of specific rodent models of development, developmental disabilities, and neurodegenerative diseases. This Core has been renamed during the present project period, reflecting a sharpening of its focus and considerable new expertise and services added during the past five years in order to be both responsive to the growing and changing needs of MRDDRC investigators and to contribute to the evolving scientific agenda of the MRDDRC. The space allocated to this Core is in the midst of a major renovation that, as of January 2005, resulted in the temporary relocation of all animals to other facilities on campus, with reassignment of the caretaker staff to those facilities. While renovation is taking place, Core services are continuing uninterrupted at those alternate locations. This description of the Rodent Models Core includes an explanation of how this Core will operate when the animals return in 2007, with newly trained staff who will operate this exceptional and fully modernized facility serving the diverse scientific needs of MRDDRC investigators using rodent models. In the description below, the present tense is used to portray resources and services that continue uninterrupted in temporary locations during the renovation, past tense is used to refer to improvements made prior to the renovation, and future tense is used to refer to new Core services that will be provided after the renovation is completed in 2007. Therefore, the description of the Rodent Models Core reflects the strengths of past accomplishments as well as the promise of future achievements.