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中文摘要
翻译
肌肉骨骼机器人与机械测试核心 肌肉骨骼机器人和机械测试中心的主要任务是提供 肌肉骨骼组织、关节和关节复合体的机械测试设施和服务。这 将通过:(1)获取共享设备和资源的组织结构来实现; (2)为测试方案和仪器的开发和使用提供专家意见 技术;以及(3)协助数据收集、分析和归档。 现有的三个测试设施将成为核心的一部分:两个单轴材料测试系统和一个 双轴测试系统。它们主要用于对软组织中的材料属性进行量化 骨头。一个新的6轴机器人测试系统正在增加,以补充这些设施。机器人 该系统将作为一个通用的测试系统,可以应用受控的三维运动 并对标本施加压力。在组织变形和关节运动的结构中需要这样的测试 两者都扮演着重要的角色,例如在关节、脊椎节段和脚。 目前有六名独立资助的调查员,他们的项目将利用核心 设施。其中两种过度使用损伤的研究机制,即重复负荷对 结缔组织的生物学和力学。两名研究人员对急性损伤机制感兴趣: 脚跟骨折和膝盖前十字韧带撕裂。另外两项研究正在进行中 治疗鞋和脊柱植入物,这两者都依赖于先进的机械测试来发现 优化设计参数。所有六名研究人员都有很强的生物力学背景。进入 对于非专家来说,测试设施和技术支持也变得越来越重要。我们的 研究基地包括强大的组织工程和关节外科项目,这两个项目都将受益 这在很大程度上得益于现代生物力学测试技术。
英文摘要
Musculoskeletal Robotics and Mechanical Testing Core The primary mission of the Musculoskeletal Robotics and Mechanical Testing Core is to provide facilities and services for mechanical testing of musculoskeletal tissues, joints, and joint complexes. This will be accomplished through: (1) an organizational structure for access to shared equipment and resources; (2) the availability of expert advice for development and use of test protocols and instrumentation techniques; and (3) assistance with data collection, analysis, and archiving. Three existing test facilities will be part of the Core: two uniaxial material testing systems, and one biaxial testing system. These are primarily used for quantification of material properties in soft tissue and bone. A new 6-axis robotic testing system is being added to complement these facilities. The robotic system will serve as a general-purpose testing system which can apply controlled three-dimensional motions and forces to specimens. Such tests are needed in structures where tissue deformation and joint motion both play important roles, such as in joints, spine segments, and feet. There are currently six independently funded investigators with projects that will make use of the Core facilities. Two of these study mechanisms for overuse injury, i.e., the effect of repetitive loading on the biology and mechanics of connective tissue. Two investigators are interested in acute injury mechanisms: heel fractures and tears of the anterior cruciate ligament in the knee. The other two studies are on therapeutic footwear and spinal implants, and both of these rely on advanced mechanical testing to find optimal design parameters. All six researchers have strong backgrounds in biomechanics. Access to testing facilities and technical support is also becoming increasingly important for non-specialists. Our Research Base includes strong programs in tissue engineering and in joint surgery, both of which will benefit greatly from access to modern biomechanical testing techniques.
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Immersive Training in Glycosciences
  • 批准号:
    10197206
  • 项目类别:
  • 资助金额:
    $95.93万
  • 财政年份:
    2018
  • 负责人:
    VINCENT CHARLES HASCALL
  • 依托单位:
Immersive Training in Glycosciences
  • 批准号:
    10424530
  • 项目类别:
  • 资助金额:
    $95.49万
  • 财政年份:
    2018
  • 负责人:
    VINCENT CHARLES HASCALL
  • 依托单位:
TSG-6: Novel Regulator of Viral-Induced Hyaluronan Synthesis in Inflamed Airways
  • 批准号:
    9069956
  • 项目类别:
  • 资助金额:
    $31.7万
  • 财政年份:
    2013
  • 负责人:
    VINCENT CHARLES HASCALL
  • 依托单位:
TSG-6: Novel Regulator of Viral-Induced Hyaluronan Synthesis in Inflamed Airways
  • 批准号:
    8849492
  • 项目类别:
  • 资助金额:
    $31.22万
  • 财政年份:
    2013
  • 负责人:
    VINCENT CHARLES HASCALL
  • 依托单位:
国内基金
海外基金
ANKLE2通过调控PINK1减轻脓毒症心肌细胞线粒体钙超载的机制研究
  • 批准号:
    CSTB2023NSCQ-MSX0603
  • 项目类别:
    省市级项目
  • 资助金额:
    10.0万元
  • 批准年份:
    2023
  • 负责人:
    许皓
  • 依托单位:
影响核膜与内质网膜结构的ANKLE2分子在衰老调控中的关键作用
  • 批准号:
    91649107
  • 项目类别:
    重大研究计划
  • 资助金额:
    60.0万元
  • 批准年份:
    2016
  • 负责人:
    朱正茂
  • 依托单位: