CCF Musculoskeletal Core Center

描述（由申请人提供）： 克利夫兰临床基金会肌肉骨骼核心中心（CCFMCC）。自从最初的MCC RFA以来，CCF的肌肉骨骼研究活动随着Joseph Lannotti博士的招募而急剧增加（一位杰出的临床肌肉骨骼研究人员）的骨科手术系主任，由彼得卡瓦纳博士招聘。（一位杰出的肌肉骨骼生物力学研究员）的生物医学工程系主任，在这两个部门建立了矫形研究中心，并招募了3名新的研究人员。这与已经强大的肌肉骨骼计划相结合，现在为我们提议的CCFMCC提供了一个基础广泛，互动和资金充足的研究基地。研究基地的研究人员目前是14个NIH R 01赠款的PI，其中9个由NIAMS资助。这清楚地表明了CCF和NIH对这项研究的承诺。ORC致力于在转化研究和丰富计划方面的合作。一个例子是每月的肌肉骨骼研究研讨会系列，扩展到凯斯西储大学，大学医院研究所和东北俄亥俄州大学医学院，以产生更广泛的东北俄亥俄州地区的协同研究。在本提案中，我们要求提供资金，每年邀请4名国家/国际肌肉骨骼研究人员，以丰富这一已经建立的活动。CCFMCC还将丰富该中心和CCF的研究，提出3个核心：肌肉骨骼成像，肌肉骨骼组织学，肌肉骨骼机器人和机械测试，每个都有高技能的主任和副主任。成像核心在我们的第一次提交中被评为优秀，并大大增加了其资源，包括microCT功能。研究基地的扩大大大增加了对软组织和矿化组织的组织学以及原位杂交的需求。组织学核心将通过高通量、可重复的方法来满足这一需求，特别是对于组织阵列、组织切片和高灵敏度、非放射性原位杂交。Cavanagh博士建立了一个机器人系统，该系统与我们现有的材料测试能力一起，形成了生物力学核心，为研究基地的研究增加了一个新的令人兴奋的维度。一个由5名杰出的肌肉骨骼研究人员组成的外部咨询委员会已经成立，以审查试点和可行性项目，并每年评估其进展情况。他们对最初提出的13个项目中的6个项目进行了严格的审查，导致2个项目被纳入本申请。总之，我们认为我们拥有所有必要的属性，可以为MCC提供高度竞争性的应用程序，从而以可以发挥作用并为肌肉骨骼研究做出更大贡献的方式增强我们的研究。

DESCRIPTION (provided by applicant): The Cleveland Clinic Foundation Musculoskeletal Core Center (CCFMCC). In the years since the original RFA for MCCs, musculoskeletal research activities have dramatically increased at CCF by the recruitment of Dr. Joseph Lannotti (an outstanding clinical musculoskeletal researcher) to the Chair of the Department of Orthopaedic Surgery, by the recruitment of Dr. Peter Cavanagh (an outstanding musculoskeletal biomechanics researcher) to the Chair of the Department of Biomedical Engineering, by the creation of the Orthopaedic Research Center in these two Departments, and by the recruitment of 3 new investigators into the Center. This, combined with an already strong musculoskeletal program, now provides a broadly based, interactive and well-funded Research Base for our proposed CCFMCC. Investigators in the Research Base currently are PIs on 14 NIH R01 grants, 9 of them funded by NIAMS. This clearly demonstrates the commitment of the CCF and NIH to this research. The ORC is committed to collaboration in translational research and enrichment programs. An example is the monthly Musculoskeletal Research Seminar Series that extends to Case Western Reserve University, University Hospitals Research Institute and NE Ohio Universities College of Medicine to generate synergistic research in the wider NE Ohio area. We ask, in this proposal, for funds to invite 4 national/international musculoskeletal researchers a year to enrich this already established activity. The CCFMCC would also enrich the research of the Center and CCF with 3 proposed cores: Musculoskeletal Imaging, Musculoskeletal Histology, and Musculoskeletal Robotics and Mechanical Testing, each with highly skilled Directors and Associate Directors. The imaging core was rated outstanding in our first submission and has added significantly to its resources, including microCT capabilities. The expansion of the Research Base has greatly increased the need for histology of soft and mineralized tissues and for in situ hybridization. The histology core would meet this need with high throughput, reproducible methods, particularly for tissue arrays, tissue sections and highly sensitive, non-radioactive in situ hybridization. Dr. Cavanagh has established a robotics system that, with our existing materials testing capabilities, forms the biomechanics core, adding a new and exciting dimension to investigations in the Research Base. An External Advisory Board of 5 outstanding musculoskeletal researchers has been assembled to review the Pilot and Feasibility Projects and for evaluating their progress on a yearly basis. Their stringent review of the 6 Projects prepared from the 13 originally proposed has led to the 2 that are incorporated into this application. In sum, we feel that we have all the necessary attributes to provide a highly competitive application for a MCC that would enhance our research in ways that can make a difference and contribute more significantly to musculoskeletal research.