Leukemia Tissue Bank

成功地将白血病的基础研究转化为临床环境的能力，以及更好地 通过实验室研究了解观察到的临床现象的相关性，是非常重要的 通过提供广泛的组织样本库以及随附的完整 病理和临床资料，取自白血病患者。OSUCCC白血病组织库 共享资源(LTBSR)是独立于CALGB白血病组织库的共享资源 1997年建立的资源，从762例同意的白血病中获得了4,500多例患者样本 俄亥俄州立大学的病人。OSUCCC LTBSR的基础设施完善，并直接隶属于我们的 领导力。具体地说，我们有一个大型的白血病组织储存库，包括白血病组织和 正常组织生殖系DNA，所有病例均伴有完整的病理、细胞遗传学和临床 临床和生物学结果的现成相关性数据。此外，有效白血病的所有要素 组织库管理，包括组织收集、标本质量控制、组织 存储、采购初始和后续样本及其病理和临床信息、数据录入 和数据库管理，以及患者同意和保密非常发达。此外， 对组织进行优先排序和分配给OUCCC内大量调查人员的程序包括 有效地到位了。最后，我们在管理这个庞大的白血病组织资源方面的成功可以从 有文件记录的样本收集和样本分发给中心和28个中心内的所有白血病研究人员 OSUCCC LTBSR发挥重要作用的出版物。在此背景下，我们认为 这一共享资源将很好地支持OSUCCC#年的研究任务 )开展高质量的血液系统恶性肿瘤基础和临床研究。目前，OSUCCC _TBSR完全由OSUCCC/机构支助提供资金。这种共享资源的具体目标是， 因此，为了：1)继续为以下方面提供中央收集、处理和最先进的存储库 从接受OSU方案治疗的白血病患者收集的样本，以及2)提供来自 LTBSR向OSUCCC内部的感兴趣的调查人员以及涉及 与俄亥俄州立大学合作研究，后者检查白血病的相关细胞和分子特性。

The ability to successfully translate basic research in leukemia to the clinical setting, as well as to better understand the relevance of observed clinical phenomena through laboratory-based research, is greatly facilitated by the availability of an extensive repository of tissue samples, with accompanying complete pathologic and clinical data, procured from leukemia patients. The OSUCCC Leukemia Tissue Bank Shared Resource (LTBSR), separate and distinct from the CALGB Leukemia Tissue Bank, is a shared resource established in 1997 with over 4,500 patient samples procured from 762 consented leukemia patients at OSU. The infrastructure of the OSUCCC LTBSR is well-established and is directly under our leadership. Specifically we have a large leukemia tissue repository, including both leukemic tissue and normal tissue germ line DNA, accompanied in all cases with complete pathologic, cytogenetic and clinical data for ready correlation of clinical and biological results. In addition, all the essentials of effective leukemia tissue bank management, including the activities of tissue collection, quality control of specimens, tissue storage, procurement of initial and follow-up samples and their pathology and clinical information, data entry and database management, and patient consent and confidentiality are very well developed. Furthermore, the procedures for prioritizing and distributing tissue to a large base of investigators within the OUCCC are effectively in place. Finally, our success in managing this large leukemia tissue resource can be seen in the documented sample collection for and sample distribution to all leukemia researchers within the CCC and 28 publications where the OSUCCC LTBSR has played a significant role. Against this background, we believe that this Shared Resource will function well in the support of the research mission of the OSUCCC in )roducing high-quality basic and clinical research in hematological malignancy. Currently the OSUCCC _TBSR is funded solely with OSUCCC/institutional support. The Specific Aims of this Shared Resource are, therefore, to: 1) Continue to provide a central collection, processing and a state-of-the-art repository for samples collected from leukemia patients treated on OSU protocols, and 2) Provide materials from the LTBSR to interested investigators within OSUCCC, as well as to outside interested investigators involved in collaborative studies with OSU, who examine relevant cellular and molecular properties of leukemia.