Molecular basis of transgenerational epigenetic inheritance in mammals

虽然长期以来人们已经认识到，从配子传递到胚胎的不仅仅是DNA，而是染色体，但非DNA成分被认为不携带关于后代最终表型的信息。然而，现在有证据表明，非DNA成分，表观遗传成分，可以在哺乳动物的表型遗传中发挥作用。这项研究将试图确定这种现象的分子性质。

While it has long been recognised that it is not just DNA, but chromosomes, that are passed from the gametes to the embryo, the non-DNA component was thought to carry no information with respect to the offspring's ultimate phenotype. However, there is now evidence that the non-DNA component, the epigenetic component, can play a role in the inheritance of phenotype in mammals. This study will attempt to determine the molecular nature of this phenomenon.