Biostatistical Core

核心C：生物统计核心的工作人员将负责为 这个方案的研究。生物统计核心由Timothy D博士监督。约翰逊 密歇根大学公共卫生学院生物统计学系。核心提供援助 在该计划的临床前和动物实验的设计，分析和解释。核心 工作人员将与项目调查人员互动，以确保适当的设计和分析方法 被使用。设计问题涉及剂量选择、随机化、测量时间和样本量 注意事项。对于数据分析，核心将确保使用有效的方法。标准图形， 采用组间比较和相关分析方法对实验结果进行初步研究 数据混合模型方法将用于在涉及重复的实验中有效使用数据。 措施约翰逊博士在动物和临床数据的设计和分析方面经验丰富。这将 确保从所有项目中获得的所有数据都将得到有效收集和适当分析。 公共卫生：总的来说，这项研究工作将开发药物范例和治疗组合， 在动物模型中靶向干细胞群体。这些临床前实验有可能 转化为临床试验。

CORE C: The staff of the Biostatistics Core will be responsible for providing biostatistical support to the research of this program. The Biostatistical Core is under the supervision of Dr. Timothy D. Johnson of the Biostatistics Department in the University of Michigan School of Public Health. The core provides assistance in the design, analysis and interpretation of preclinical and animal experiments of the program. Core personnel will interact with project investigators to ensure that appropriate designs and methods of analysis are used. Design issues involve selection of dose, randomization, timing of measurements and sample size considerations. For data analyses, the core will ensure that efficient methods are used. Standard graphical, group comparison and correlation methods of analysis will be used for initial investigation of the experimental data. Mixed model methods will be used for efficient use of the data in experiments involving repeated measures. Dr. Johnson is experienced in the design and analysis of both animal and clinical data. This will ensure that all data obtained from all Projects will be collected efficiently and analyzed appropriately. Public Health: Overall, this research effort will develop drug paradigms and treatment combinations for target stem cell populations in animal models. These pre-clinical experiments have the potential for translation to clinical trials.