The Molecular Basis of Head and Neck Cancer Biology, Treatment and Prevention

为头颈癌患者设立的卓越研究专项计划 《头颈部肿瘤生物学、治疗和预防的分子基础》将 显著改善治疗结果并降低与这一毁灭性事件相关的发病率和死亡率 恶毒。这些目标将通过提高对分子的理解和应用来实现 生物学致力于检测、预防、治疗、选择和开发新的治疗方法 头颈部癌症。我们正在进行的假设是，对分子基础的理解增加 治疗将允许更精确的个性化患者选择，从而减少病态治疗和 生活质量的提高，以及更好地控制转移和更早发现或 第二原发癌的预防。 我们建议继续这一由四个主要项目组成的综合翻译研究计划 探索1)。)更具体的治疗选择，适用于有可能通过放射治疗治愈的患者 化疗；2.)新的小分子细胞凋亡调节抑制剂，以提高化疗/放射敏感性； 3.)通过制定完善的预防战略提高存活率；以及关键小的作用 分子和化学放射测序，以优化治疗结果。这些主要的翻译 项目得到持续的非常成功的职业发展和发展研究的补充 程序。所有孢子研究都得到了三个核心资源的支持，并在我们的 初始资助期(管理和转化性试验支持、生物统计学、组织和 组织病理学)。重点是持续不断地对所有计划和核心进行科学审查 通过利用已设立的业务委员会、高级咨询理事会和外部资源 审查委员会由癌症研究领域的基础和临床专家科学家组成。强壮 我们最初资助期的机构承诺在这次更新中显著增加。 支持设备需求的应用程序，我们的开发研究计划并提供更多 灵活地对作为这些孢子的结果而作出的新发现进行进一步调查 项目和协作。这种头颈孢子是加州大学的一个完整的组成部分。 密歇根综合癌症中心。我们已经纳入了癌症中心核心的广泛使用 设施、临床和实验室资源，我们严重依赖经验丰富的癌症中心 领导力。由经验丰富的临床/基础协作者组成的一流团队与高级机构相结合 承诺和优先事项，以及广泛的患者资源，提供了一个出色的研究环境 将确保在实现总的孢子目标方面继续取得成功。

A Specialized Program of Research Excellence for patients with cancer of the head and neck entitled 'The Molecular Basis of Head and Neck Cancer Biology, Treatment and Prevention" is proposed that will significantly improve treatment results and reduce morbidity and mortality associated with this devastating malignancy. These goals will be achieved through improved understanding and application of molecular biology to the detection, prevention, treatment selection and development of new therapies for patients with head and neck cancers. Our ongoing hypothesis is that increased understanding of the molecular basis for treatment will allow more precise individualized patient selection that will result in less morbid therapy and improved quality of life, in addition to the possibility of better control of metastases and earlier detection or prevention of second primary malignancies. We propose continuation of this integrated translational research program consisting of four major projects that explore 1.) more specific treatment selection for patients likely to be cured with radiation or chemotherapy; 2.) new small molecule inhibitors of apoptosis-regulation to increase chemo/radiosensitivity; 3.) improved survival through development of sound prevention strategies; and 4.) the role of critical small molecules and chemoradiation sequencing for optimizing treatment results. These major translational projects are complemented by ongoing highly successful Career Development and Developmental Research Programs. All SPORE studies are supported by three Core Resources with demonstrated success in our initial funding period (Administration and Translational Trials Support, Biostatistics, and Tissue and Histopathology). Emphasis is placed on continued ongoing scientific review of all programs and core resources through utilization of an established Operations Committee, Senior Advisory Council and External Review Committee comprised of expert basic and clinician scientists in the field of cancer research. Strong institutional commitment in our initial funding period has been increased significantly in this renewal application to support equipment needs, our Developmental Research Program and provide increased flexibility to pursue further investigations of novel discoveries that are made as a result of these SPORE projects and collaborations. This Head and Neck SPORE is a fully integrated component of the University of Michigan Comprehensive Cancer Center. We have incorporated extensive use of Cancer Center core facilities and clinical and laboratory resources, and we draw heavily on experienced Cancer Center leadership. Superb teams of experienced clinical / basic collaborators combined with high institutional commitment and priority, and extensive patient resources provide an outstanding research environment that will ensure continued success in achieving overall SPORE goals.