Seizure Location Using Signal Processing Techniques

描述(由申请人提供)：为P.I.设计了一个研究和职业发展计划，以设计新的方法来解释癫痫患者的长期脑电(EEG)。颅内监测已被确定为癫痫切除手术前最特异的癫痫定位方法。现有的解释方法已被证明不足以解释源于新皮质的癫痫发作。来自信号处理领域的定量技术可以应用于脑电信号，以揭示时空模式，为癫痫发作的起源提供线索。将对癫痫患者大脑中神经元网络组织的异常进行测绘，并通过对从正常猕猴获得的可比记录进行同步性评估和电流源密度分析来验证异常发现。这些发现，连同癫痫发作期间脑电记录的行为，将被研究以确定发作期脑电模式，并深入了解其癫痫发生的潜在机制。这将为制定准确解释颅内记录的方法提供一个框架。为这位私家侦探设计了专门针对她的学术需求的正式培训计划，补充了她之前的临床培训以及在工程和数学方面的经验。这将包括：电生理学、信号处理、灵长类动物研究和临床癫痫学专家的指导，以及生物医学信号处理、统计学和研究伦理学的课程工作。这一协调的研究和培训计划的目标是完成P.I.为独立研究人员的职业生涯做准备，具备进行多学科合作调查的技能，并发展确定电生理学和癫痫研究的新方向的能力。

DESCRIPTION (provided by applicant): A program of research and career development has been designed for the P.I. to devise new methods for interpreting long-term intracranial electroencephalograms (EEG) of epilepsy patients. Intracranial monitoring has been established as the most specific method of seizure localization prior to resective epilepsy surgery. Existing methods of interpretation have proven inadequate for seizures originating in neocortex. Quantitative techniques drawn from the field of signal processing can be applied to EEG signals to reveal spatio- temporal patterns that provide clues to the seizure origin. Mapping of abnormalities in neuronal network organization in the brains of epilepsy patients will be performed, with validation of abnormal findings by evaluation of synchrony and current source density analysis in comparable recordings obtained from normal macaque monkeys. These findings, together with the behavior of EEG recordings during epileptic seizures, will be studied to define ictal EEG patterns and gain insight into their underlying mechanisms of epileptogenesis. This will provide a framework for the formulation of methods for the accurate interpretation of intracranial recordings. A formal training program has been designed for the P.I. specifically tailored to her academic needs, complementing her prior clinical training and experience in engineering and mathematics. This will include: mentoring by experts in electrophysiology, signal processing, primate studies and clinical epileptology, and course work in biomedical signal processing, statistics and research ethics. The goal of this coordinated program of research and training is to complete the preparation of the P.I. for a career as an independent researcher, with the skills to perform multidisciplinary collaborative investigation and a developed capacity to define new directions for research in electrophysiology and epilepsy.