ACOSOG Non Competing Renewal

美国外科医生学会肿瘤学小组(ACOSOG)致力于改善外科手术的护理 肿瘤学患者通过创新的临床研究计划实现三个具体目标： 1.测试可提高应答率和治愈率并减少发病率和残疾的新疗法 与癌症护理有关。 2.结合临床试验进行基础科学研究，以更深入了解疾病的生物学基础 和治疗。 3.支持个人成员和研究人员网络让患者参加试验并履行科学使命 ACOSOG的。 ACOSOG的科学组合专注于特定于分子的研究 以及影像分析、新辅助疗法和靶向或新的外科疗法。 有四个科学委员会，包括一个基础科学委员会和三个 疾病委员会：乳房、胃肠道(GIST、胰腺和直肠)和 胸部(肺和食道)。描述了ACOSOG试验的三个科学目标 包括：a)通过提高预测的准确性来加强风险分层 通过成像和分子图谱；b)提高总体应答率和 通过应用新辅助疗法监测个体反应；以及c) 研究新的、有针对性的和外科治疗方法以维持肿瘤预后，同时 个性化 回复监控 减少毒性和残疾，从而提高生活质量。 为了制定ACOSOG的科学议程，疾病委员会与基础科学委员会合作 酌情确保开展以科学为导向的试验。科学委员会还与 行政委员会和同行审议和优先委员会，以确保成员的支持 作为优先顺序、协调和高质量的科学。所有学科以及护理和患者倡导者都是 代表并通过同行审议委员会进程提供议定书反馈。《基础科学》 委员会和ACOSOG生物质谱库确保适当地获取和存储样本以进行 每项临床试验都纳入了科学研究。 为了实现科学目标，ACOSOG使用由五个关键要素组成的基础设施进行临床试验 包括：1)位于北卡罗来纳州达勒姆的行政协调中心(行政协调中心或运营办公室) 在杜克临床研究所内；2)位于明尼苏达州罗切斯特的生物统计学，在梅奥临床癌症研究所内 中心；3)科学和组织方面的领导；4)成员和网络；5)生物质学库 位于密苏里州圣路易斯，位于华盛顿大学内。

The American College of Surgeons Oncology Group (ACOSOG) is dedicated to improving the care of the surgical oncology patient through an innovative clinical research program addressing three specific aims: 1. To test novel therapies that may increase response rates and cure rates and reduce morbidities and disabilities associated with cancer care. 2. To conduct basic science studies in conjunction with clinical trials to better understand the biologic basis of diseases and treatments. 3. To support individual members and investigator networks to accrue patients to trials and fulfill the scientific mission of ACOSOG. The scientific portfolio of ACOSOG is focused on investigations specific to molecular and image profiling, neoadjuvant therapies, and targeted or novel surgical therapies. There are four scientific committees including a Basic Science Committee and three disease committees: Breast, Gastrointestinal (GIST, pancreas, and rectum) and Thoracic (lung and esophagus). Three scientific aims are described for ACOSOG trials including: a) to enhance risk stratification by increasing the accuracy of prognostication through imaging and molecular profiling; b) to improve overall response rates and monitor individual responses through the application of neoadjuvant therapies; and c) to investigate novel, targeted, and surgical therapies to maintain oncologic outcomes while Individualized Response Monll reducing toxicities and disabilities thereby improving quality of life. To set the scientific agenda of ACOSOG, the disease committees work with the Basic Science Committee to ensure, where appropriate, the development of science-driven trials. The scientific committees also work closely with the administrative committees & the Peer-Review and Prioritization Committee to ensure membership support as well as prioritization, coordination, and quality science. All disciplines as well as Nursing & Patient Advocates are represented and provide protocol feedback through the Peer-Review Committee process. The Basic Science Committee & ACOSOG Biospecimen Bank ensure the appropriate acquisition and storage of samples to conduct the scientific studies integrated into each clinical trial. To accomplish the scientific aims, ACOSOG conducts clinical trials using an infrastructure consisting of five critical components, including the: 1) Administrative Coordinating Center (ACC or Operations Office) located in Durham, NC within the Duke Clinical Research Institute; 2) Biostatistics, located in Rochester, MN, within the Mayo Clinical Cancer Center; 3) Leadership, both scientific and organizational; 4) Membership and Networks; and 5) the Biospecimen Bank located in St. Louis, MO, within Washington University.