Body Burden of PAHs and Cardiovascular Disease in the United States

描述（由申请人提供）：多环芳烃（PAHs）是由烟草、煤炭和石油等有机物质不完全燃烧产生的环境和职业致癌物。除了导致肺癌外，暴露于高水平的多环芳烃被认为会导致动脉粥样硬化，并导致心血管疾病的发病率增加。考虑到烟草烟雾暴露、环境空气污染和职业危害导致的死亡人数，多环芳烃可能是心血管疾病高患病率和高死亡率的一个重要因素。然而，多环芳烃与心血管疾病之间明确的暴露-反应关系尚未得到证实。虽然在动物实验中多环芳烃暴露已被证明与心血管疾病指标相关，但这种关系尚未在大规模人群中得到充分研究。利用1999年以来收集的国家健康和营养检查调查（NHANES）的数据，这项拟议的研究将调查尿中多环芳烃代谢物与自我报告和实验室测量的心血管疾病之间的关系。有关个人职业、接触烟草烟雾和居住在有清洁室内空气法的地区的信息将包括在内，以调查与多环芳烃接触有关的因素。具体目标是：1。目的：确定暴露于多环芳烃（PAHs）是否与美国儿童和成人心血管疾病的临床和自我报告指标相关。确定在家中或工作场所暴露于多环芳烃环境源是否与多环芳烃尿液代谢物水平升高有关。3. 在控制吸烟状况和暴露于二手烟的情况下，确定暴露于高水平环境空气污染是否与尿中多环芳烃代谢物水平升高有关。心血管疾病仍然是美国最大的单一死亡原因。了解多环芳烃暴露对心血管疾病发展的贡献将为预防心血管疾病的新策略提供重要见解。本研究的结果可用于影响心血管疾病预防的政策决策和资源分配。

DESCRIPTION (provided by applicant): Polycyclic aromatic hydrocarbons (PAHs) are environmental and occupational carcinogens that are produced by the incomplete combustion of organic material, such as that from tobacco, coal, and petroleum. In addition to causing lung cancer, exposure to high levels of PAHs is hypothesized to contribute to atherosclerosis and lead to increased rates of cardiovascular disease. Considering the number of deaths attributable to tobacco smoke exposure, ambient air pollution, and occupational hazards, PAHs may be a significant contributor to the high prevalence and mortality rate of cardiovascular disease. However, a clear exposure-response relationship between PAH and cardiovascular disease has not been demonstrated. While PAH exposure has been shown to be associated with indicators of cardiovascular disease in animal experiments, this relationship has not been studied adequately in large human populations. Using data from the National Health and Nurition Examination Survey (NHANES) collected since 1999, this proposed study will investigate associations between urinary metabolites of PAHs and self-reported and laboratory measures of cardiovascular disease. Information regarding individuals' occupation, exposure to tobacco smoke and residence in areas with clean indoor air laws will be included to investigate factors associated with PAH exposure. The specific aims are: 1. To determine if exposure to polycyclic aromatic hydrocarbons (PAHs) is associated with clinical and self- reported indicators of cardiovascular disease in children and adults in the U.S. 2. To determine if exposure to environmental sources of PAHs at home or in the workplace is associated with elevated levels of urinary metabolites of PAHs. 3. To determine if exposure to high levels of ambient air pollution is associated with elevated levels of urinary metabolites of PAHs when controlled for smoking status and exposure to secondhand smoke. Cardiovascular disease remains the single largest cause of death in the United States. Understanding the contribution of PAH exposure to the development of cardiovascular disease will provide important insight into new strategies to prevent cardiovascular disease. Results of this proposed study can be used to influence policy decisions and resource allocation for the prevention of cardiovascular disease.