Molecular dissection of allergen sensitisation and immunotherapy: direct application to precision medicine in treatment of asthma

哮喘是全球主要的健康负担，具有巨大的社会经济影响。大多数哮喘患者都是过敏的。过敏原免疫治疗是改变自然疾病进程的唯一治疗方法，但在许多接受治疗的患者中无效，缺乏用于患者选择和治疗成功的免疫监测的强大实验室生物标记物。因此，过敏原免疫治疗不会提供给大多数无限期依赖药物的患者。这项研究将解决这些需求。

Asthma is a major global health burden with huge socioeconomic impact. Most asthmatic patients are allergic. Allergen immunotherapy is the only treatment to alter the natural disease course, but does not work in many treated patients, and robust laboratory biomarkers for patient selection and immune monitoring of treatment success are lacking. Therefore, allergen immunotherapy is not offered to most patients who then rely on medications indefinitely. This research will address these needs.