Neuroimaging Core

神经成像核心的主要目标是服务于使用核磁共振的临床项目1和2 图像采集与处理技术。核心提供了对结构的定量测量 磁共振成像(SMRI)、磁共振弥散张量成像(DTI)和功能磁共振成像(FMRI)，并准备定量 结果由生物统计核心进行分析。核心利用了最先进的高场图像 扫描仪MRI技术，并确保优化的脉冲序列，用于新生儿和年轻人的成像 儿童(3T西门子Allegra仅限头部)和青少年。(3T GE)。核心将提供完善的 和经过验证的图像分析方法，并将在这些需求的驱动下引入新方法 项目。鉴于我们多学科小组的专业知识和我们的 对该项目至关重要的其他大型国家项目的研究人员 (生物信息学研究网络BIRN，全国医学图像计算联盟NA-MIC，NLM- 赞助的洞察工具包ITK开发)，我们不仅将为具有良好 已建立方法学，但将继续开发先进的、新颖的图像处理工具，以满足 把场地向前推进。这一核心使中心调查人员能够利用最佳方法进行图像数据分析 使用全方位的MRI功能，从而使成像研究能够解决高度相关的问题 精神分裂症高危人群脑发育及其改变的临床前研究。 在学习中关注神经成像的最早年龄范围(新生儿到6岁的受试者) 纵向研究中的大脑发育(这提供了横断面研究无法达到的视角 样本)，其次关注儿童和青少年大脑结构和功能的变化 精神分裂症的遗传风险，加上新的创新图像分析工具的应用，都在 根据美国国立卫生研究院资助的项目的使命，更好地了解疾病的原因和来源。

The primary objective of the Neuroimaging Core is to serve the clinical Projects 1 and 2 which utilize MRI image acquisition and processing technology.. The core provides quantitative measurements of structural MRI (sMRI), MR Diffusion Tensor Imaging (DTI), and functional MRI (fMRI), and prepares the quantitative results for analysis by the Biostatistics Core. The core utilizes images from state-of-the-art high-field scanner MRI technology, and ensures optimized pulse sequences for imaging of neonates and young children (3T Siemens Allegra head-only) and adolescents. (3T GE). The core will provide well established and validated image analysis methods and will also introduce novel methods driven by the needs of these projects. Given the specialized expertise of our multi-disciplinary group and the close collaboration of our researchers with other large national programs which are of crucial importance for this project (Bioinformatics Research Network BIRN, National Alliance of Medical Image Computing NA-MIC, NLM- sponsored Insight Toolkit ITK developments), we will not only provide service to projects with well- established methodology, but will continue to develop advanced, novel image processing tools necessary to advance the field. This Core enables Center investigators to utilize optimal methods for image data analysis using the full range of MRI capabilities, and thus enables imaging research which addresses highly relevant pre-clinical research of brain development and alterations thereof in subjects at risk for schizophrenia. Focusing on the earliest age range possible for neuroimaging (neonates to 6 year old subjects) with studying brain growth in a longitudinal study (which provides a perspective that is unattainable with cross-sectional samples), and secondly focusing on altered brain structure and function in children and adolescence at genetric risk for schizophrenia, coupled with applying novel innovative image analysis tools, are all in accordance with the mission of NIH funded projects to get better insight into cause and origin of disease.